RESUMO
Introduction: hyperhomocysteinemia is associated with premature peripheral vascular, cerebrovascular and coronary artery disease. The relation between B-vitamins and vascular disease re- mains poorly defined. Patients with mild hyperhomocyteinemia are asymptomatic until the third or fourth decade when premature coronary artery disease may develop, as well as recurrent arterial and venous thrombosis. Increased plasma total homocysteine [tHcy] level is the most common cause of mortality in patients with type 2 diabetes
Aim of the work: The study was carried out to access the role of homocysteine, vitamin B12 and folic acid as risk factors for deep vein thrombosis in type 2 diabetes mellitus
Material and Methods: The present study was conducted on 45 diabetic female patients of type 2, they were dived into 3 groups: group I [GI]; 15 patients having recently diagnosed diabetes [less than 4 months], group II [GII]; 15 patients having diabetes for the past 7-10 years and not suffering from any diabetic complications and group III [GIII] 15 patients having diabetes for the past 7-1 1 years complicated with deep vein thrombosis. All diabetic patients in GI, I1 and III were treated with metformin and were not taking vitamin supplementation before the study. Also 15 healthy females of matched age were involved in the study as a control group. In all groups and control plasma homhocysteine, serum folic acid and vitamin B12 were measured, also fasting serum glucose and glycosylated hemoglobin [HbA1c] were measured to all diabetic groups and control
Results and Conclusion: there were significant increase in plasma tHcy levels and significant decrease in serum folate levels in diabetic females in all groups [GI, IGIIand GIII] as compared to the control group, also there were significant increase in serum folate and significant de- crease in plasma tHcy levels in uncomplicated diabetic females in GII as compared to GI and GIII. Serum folate and vitamin B12 levels were significantly decreased while plasma tHcy levels were significantly increased in GIII as compared to controls, GI and GII. These findings suggest that people with type 2 diabetes complicated with deep vein thrombosis and treated with metformin without vitamin supplementations have elevated levels of plasma tHcy and increasing risk factor for vascular diseases. Therefore, we recommended those people to consume adequate quantities of fresh green vegetables and fruits and to take folate, vitamin B12 supplementation