RESUMO
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.
Assuntos
Animais , Humanos , Camundongos , Antineoplásicos Fitogênicos , Química , Farmacologia , Linhagem Celular Tumoral , Cristalografia por Raios X , Diterpenos do Tipo Caurano , Química , Farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Medicamentos de Ervas Chinesas , Química , Farmacologia , Células HL-60 , Isodon , Química , Lipopolissacarídeos , Farmacologia , Macrófagos , Estrutura Molecular , Óxido Nítrico , Ressonância Magnética Nuclear Biomolecular , Componentes Aéreos da Planta , QuímicaRESUMO
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.