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1.
Chinese Journal of Medical Genetics ; (6): 467-469, 2007.
Artigo em Chinês | WPRIM | ID: wpr-247290

RESUMO

<p><b>OBJECTIVE</b>To investigate the relation between the alleles of HLA-DRB1*04 and outcome of HBV infection.</p><p><b>METHODS</b>The alleles of HLA-DRB1*04 were detected by polymerase chain reaction-sequence specific primer (PCR-SSP). The frequency of allele of HLA-DRB1*04 in four groups[106 asymptomatic HBsAg carriers (group ASC), 93 chronic hepatitis B patients (group CHB), 77 patients with hepatitis B cirrhosis and 102 cases of spontaneous recovery after HBV infection (control group)] were studied, and the frequency of that in different replication of HBV was also studied.</p><p><b>RESULTS</b>The frequency of allele of HLA-RB1*04 in groups ASC, CHB and hepatitis B cirrhosis was markedly higher than that of control group (25.94%, 26.34%, 27.92% respectively versus 14.22%, P< 0.01); the frequency of HLA-DRB1*0401 in groups ASC, CHB and hepatitis B cirrhosis was also higher than that of control group (20.91%, 24.49%, 22.09% respectively versus 8.62%, P< 0.05, P< 0.01,P< 0.05 respectively); the frequency of HLA-DRB1*0405 in groups ASC, CHB and hepatitis B cirrhosis was lower than that of control group (3.64%, 2.04%, 3.49% respectively versus 15.52%, P< 0.01, P< 0.01, P< 0.05 respectively ). There was no statistical significance in the allele frequency of HLA-DRB1*04 among groups ASC, CHB and hepatitis B cirrhosis (P> 0.05), and the same result was observed in different replication of HBV (P> 0.05).</p><p><b>CONCLUSION</b>HLA-DRB1*04 gene is one of the factors which determine the outcomes of HBV infection, while it has no influence on HBV replication.</p>


Assuntos
Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Alelos , Frequência do Gene , Predisposição Genética para Doença , Genética , Antígenos HLA-DR , Genética , Cadeias HLA-DRB1 , Hepatite B , Genética , Patologia , Reação em Cadeia da Polimerase , Polimorfismo Genético , Genética , Prognóstico
2.
Journal of Central South University(Medical Sciences) ; (12): 430-432, 2005.
Artigo em Chinês | WPRIM | ID: wpr-813542

RESUMO

OBJECTIVE@#To analyze the main pathogens of infection after the liver transplantation and their antibiotic resistant patterns.@*METHODS@#The main pathogens of infection after the liver transplantation were retrospectively analyzed. Using 3-dimensional tests, ESBLs (extended-spectrum beta-lactamase), and AmpC were detected among the Gram negative bacilli. beta-Lactamase and Van gene in Enterococcus were determined by the standard agar dilution susceptibility tests and Nitrocefin respectively.@*RESULTS@#The main infected strains were Enterococcus faecalis (15.0%), Enterobacter cloacae (13.9%), fungus (13.3%), and Escherichia coli (10.7%) after the liver transplantation. Among them, 32.4% of Enterobacter cloacae and 36.8% of Escherichia coli produced ESBLs; 33.8% of Enterobacter cloacae and 10.5% of Escherichia coli. produced AmpC beta-lactamases. The detectable rate of VanA gene in Enterococcusfaecalis and Enterococcus faecium was 7.5% and 11.1%; VanB was 3.8% and 7.4%; VanC was 1.3% and 0, respectively.@*CONCLUSION@#The infection mainly occurs in the intestinal tract after the liver transplantation. The production of ESBLs and AmpC beta-lactamases is the main mechanism of antibiotic resistance. The increased detectable rate of vancomycin-resistant Enterococcus should be paid attention to.


Assuntos
Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Farmacorresistência Bacteriana , Genética , Enterobacteriaceae , Infecções por Enterobacteriaceae , Microbiologia , Cirrose Hepática , Cirurgia Geral , Neoplasias Hepáticas , Cirurgia Geral , Transplante de Fígado , Testes de Sensibilidade Microbiana , Complicações Pós-Operatórias , Microbiologia , Estudos Retrospectivos , Resistência a Vancomicina , Genética
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