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OBJECTIVE To boost access to medical insurance for drugs and improve the accessibility and affordability of drugs. METHODS The current status of the application of international and domestic drug Managed Entry Agreement （MEA）were investigated through literature research method and other methods ，and analyzed comparatively from the aspects of the scope of agreement drugs ，the types of agreements and the content of the agreement ，etc. The problems existing in the application of drug MEA in China were summarized to put forward the suggestions. RESULTS & CONCLUSIONS The UK ，Australia and Italy had rich experience in the application of drug MEA ，and the operation management mechanism were complete. The scope of drugs included in MEA in these countries were relatively broad and the types of agreements were relatively diversified. In China ，drugs included in MEA were mainly oncology drugs and rare disease drugs. The types of agreements mainly included “finance-based agreements”and effect guarantee/effect-based payment in individual-level of“performance-based agreements ”. China ’s evidence collection platform was imperfect and lacked standardized process of MEA. It is suggested that stakeholders should consider increasing the types of drugs ，diversified types of agreements ，improving the accuracy and continuity of evidence collection ， establishing a standardized process for MEA.
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OBJ ECTIVE To introduce adjusted limited dependent variable mixed model （ALDVMM）and study its application in mapping research ，so as to provide reference for pharmacoeconomic evaluation that needs to obtain health utility value through mapping. METHODS Using the method of literature research ，ALDVMM was introduced from the aspects of development background，model principle ，model determination and test ，model advantages and the current application of the model in empirical research. RESULTS & CONCLUSIONS ALDVMM is a mixed model developed by foreign scholars for the truncation and multimodality phenomenon of EuroQoL group ’s 5D（EQ-5D）at the health utility value 1. Compared with the traditional model，ALDVMM is feasible and has more advantages ，and can more effectively and flexibly capture the actual distribution of EQ-5D and deal with the boundary value problem ，which is helpful to obtain the health utility value more accurately and efficiently and carry out high-quality pharmacoeconomic evaluation.
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OBJECTIVE：To inve stigate the current situation of clinical pharmacists ’job stress and presenteeism behavior in tertiary hospitals of China and study their correlation. METHODS ：Using the Brief Job Stress Questionnaire （BJSQ）and the presenteeism behavior individual questionnaire ，a survey of 623 clinical pharmacists in 311 tertiary hospitals from 31 provinces in China was conducted ；by establishing Logistic model between job stress ，its various dimensions （job demand ，job control ， support）and presenteeism behavior ，the correlation analysis was performed for their survey results. RESULTS ：The average job pressure of the interviewed clinical pharmacists was 36.75 points；the probability of presenteeism behavior was 20.38％. Logistic regression model analysis results showed that job stress and its two dimensions （job demand ，job control ）had a significant positive correlation with presenteeism behavior （P＜0.05）. CONCLUSIONS ：The job stress of clinical pharmacists in tertiary hospitals in my country is relatively high ，which is also the main reason for their presenteeism behavior. Job stress can be reduced （such as increasing the staffing appropriately ，providing reasonable rest time ，improving the job substitution of clinical pharmacists ）to reduce the prevalence of presenteeism behavior.
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ABSTRACT OBJECTIVE：To analyze the job stress of hospital pharmacists and its measurement methods，and to provide reference for improving the quality of related researches about the work stress of hospital pharmacists. METHODS：Related literatures about the job stress of hospital pharmacists were retrieved from CJFD，VIP，Wanfang database，Web of Science， SciFinder，Springer Link and other databases during database establishment to Aug. 2019，using“Hospital”“Pharmacist”“Stress” “Scale”as Chinese keywords，“Hospital”“Pharmacist”“Stress”“Pressure”“Scale”as English keywords. The research status was explored，and the measurement methods for work stress of hospital pharmacists were summarized. RESULTS：There were many researches on the job stress of pharmacists at abroad，including the stress status，causes，the results of stress，the model of action mechanism，etc.，but there were some problems such as long time ago and outdated data；while the related researches in China were relatively rare，and there was still a lack of comprehensive and systematic research on the job stress of hospital pharmacists. Most researches at home and abroad used the scale to measure job stress of hospital pharmacists，including the special scale for hospital pharmacists（such as the pressure source scale and the pressure list of hospital pharmacists）and the general scale for general employees（such as health occupational stress survey，work stress items and perceived psychological stress scale）. Among them，pressure source scale of hospital pharmacists was relatively consistent with the job characteristics of hospital pharmacists in China，while the other scales had problems of less coverage，too many items，and not conforming to job characteristics of hospital pharmacists in China. CONCLUSIONS：In order to improve the research quality related to job stress of hospital pharmacists，it is necessary to adjust the existing scale or develop a new measurement scale in order to measure the real work pressure of Chinese hospital pharmacists and provide reference for improving the quality of work of hospital pharmacists and improving the level of clinical pharmaceutical care