Compound nutritional therapy promote pressure ulcers healing on patients with end-stage liver disease / 中国实用护理杂志

Objective To study the effect of compound nutritional therapy on end-stage liver disease patients with pressure ulcers at Ⅱ phase got from outside the hospital. Methods A total of 101 end-stage liver disease patients with Ⅱ phase pressure ulcers were divided into the observation group (50 cases) and the control group (51 cases) by random digits table method. The control group was treated by conventional diet and drug, and the treatment group was treated by compound nutritional therapy except the conventional diet and drug. The pressure ulcers were assessed daily and the patients were reviewed weekly during treatment. The outcomes of the difference of wound healing and nutritional status improving were compared between the two groups. Results After 14 d treatment, the total of wound healing cure rate was 42.6% (29/68), the total effective rate was 94.1% (64/68) in the observation group, the total of wound healing cure rate was 27.6%(18/65), the total effective rate was 73.8%(48/65) in the control group, and there was significant difference between two groups (χ2=12.726, P=0.005). The healing time was (12.87±2.46) d in the observation group, significantly shorter than that in the control group (17.26±3.51) d, there was significant difference (t=2.760, P=0.005). Conclusions For the end-stage liver disease patients with pressure ulcers at Ⅱ phase got from outside the hospital, compound nutrition therapy can improve the nutritional status, promote the pressure ulcers healing, reduce the economic burden and improve the overall curative effect.

Association between CD28 expression and juvenile idiopathic arthritis / 国际儿科学杂志

Objective To investigate the clinical significance of CD28 expression on peripheral blood T lymphocytes in children with juvenile idiopathic arthritis (JIA).Methods Flow cytometry and tri-color direct immunofluorescence were used to examine CD3 + T lymphocyte subsets and CD28 expression in whole blood (using the no-wash method) from 36 children with JIA.Results During the active phase of disease,the frequency of CD28 + expression on both CD4 + and CD8 + T cells in the peripheral blood of children with JIA was significantly lower than in normal controls (P ＜ 0.01).The frequency of CD4 + CD28-T cells in the peripheral blood of children with JIA was significantly higher than in normal controls (P ＜ 0.01).CD4 + T cell counts in the peripheral blood of children with JIA,which were mostly of the CD4 + CD28-T cell subtype,were significantly higher than in normal controls (P ＜ 0.01),whereas the CD8 + T cell count was significantly reduced (P ＜0.01).During the resting phase,CD4 +/CD8 + T cell counts and CD28 expression in the peripheral blood of children with JIA were significantly different from normal controls (P ＞ 0.05).Conclusions The frequency of CD4 + CD28-T cells can be used as an indicator of the active phase of JIA.CD4 + T cell and CD4+ CD28-T cell apoptosis was inhibited in JIA patients.These immune-active T lymphocytes with continued survival can promote the occurrence and development of JIA.

Progress in research of P-selectin and Henoch-Sch(o)nlein purpura / 临床儿科杂志

Henoch-Schonlein purpura (HSP) is the most common vasculitis disease in childhood.It is a multisys-tern disease that most commonly affects skin,joints,gastrointestine and kidneys.The causes and pathogenetic mechanisms underlying HSP have not been understood yet.Recently great progress have been made on HSP and attention has been paid to the relationship between P-selectin and HSP.This article summarizes recent work in the advancement of P-selectin and HSP.