Fuzitine: A New Aporphine Alkaloid Isolated from Aconitum carmichaeli Debx / 第二军医大学学报

A new aporphine alkaloid, named fuzitine, was isolated from the tuber of Aconitum carmichaeli Debx. Its chemical structure was identified by the chemical, UV, IR, MS and NMR spectra analysis.

Constituents and Anti-virus Activity of Essential Oil from Cayratia japonca / 第二军医大学学报

Essential oil of Cayratia japonica was separated into 85 peaks by means of GC/MS/DS and 30 peaks of them were identified. The oil showed pronounced antiviral activities against influenza virus A, in vivo and herpes simplex virus 1 (HSV-1) in vitro. The inhibitory effect of the oil on replication of HSV-1 in Hela cells was comparable to that of acyclovir (ACV).

A New Cardiac Principle Isolated from Jiangyou Fuzi (Aconitum carmichaeli Debx.) / 第二军医大学学报

Uracil (I) (2,4-Diketo-pyrimidine) was isolated from the radix aconiti collected from Jiangyou region of Sichuan Province.The chemical structure of this principle was determined by elemental analysis,IR,UV,MS,'H and 13C-NMR spectral data. The experiments were made to study the effect of uracil (I) on the cardiac contractile force and beating rate of the isolated toad hearts in comparison with uracil (II) (artificial synthesis). The results indicated that the 5?mol/L of uracil (I) and uracil (II) both had the effect of increasing the amplitude of myocardial contraction (P0.05) at 3 and 5 min. When the concentration was increased to 10 and 20?mol/L, the amplitudes of myocardial contraction were more incremental and 3 min later,the estimated value of uracil (I) and uracil (II) to increase the amplitude of myocardial contraction by 50% approached to 4.17 and 4.68, respectively. As described above, uracil (I) is a new cardiotonic in Jiangyou Fuzi.

Isolation and Identification of Chemical Constituents in the Fruit Peels of Sinocitrus chuana Hort / 第二军医大学学报

Chemical constituents in the mature fruit peels of Sinocitrus chuana Hort were studied systematically. Five compounds were isolated and identified. They were hesperidin( Ⅰ), nobiletin(Ⅱ) tengeretin(Ⅲ), 4', 5, 7, 8-tetramethoxyflovones(Ⅳ) and synephrine(Ⅴ). Of them the fourth was isolated from this genus for the first time.