Clinical analysis of minimally invasive surgery and drug treatment for hypertensive cerebral hemorrhage / 重庆医学

Objective To compare the clinical efficacy of minimally invasive removal of intracranial hematomas and medical con-servative treatment for hypertensive cerebral hemorrhage .Methods A total of 75 patients with hypertensive cerebral hemorrhage were collected and randomly divided into two groups according to the treatments :38 patients treated with conservative medicine and 37 patients treated with minimally invasive removal of intracranial hematomas based on standard drug therapy .Neurological impair-ment and recovery of self-care ability of patients in both groups before and after three weeks and six weeks of treatment were scored by National Institute of Health Stroke Scale (NIHSS) .Changes of diffusion tensor imaging before treatment and after two weeks of treatment were evaluated by fractional anisotropy value (FA) .Results There was no significant difference between neurological im-pairments of the patients in two groups before treatment .But the recovery degree of functional impairment and muscle nerve in min-imally traumatic treatment group was more significant than those in the conservative medical treatment group after treatments . There was significant difference between two groups (P< 0 .05) .Conclusion Minimally traumatic of hematomas is an effective method of treating hypertensive intracerebral hemorrhage .

Clinical evaluation on nasal endoscopic surgery for rhinogenous optic function damage / 中国医师进修杂志

Objective To evaluate the diagnosis and efficiency of nasal endoscopic surgery treatment for rhinogenous optic function damage (ROFD).Methods The clinical data of 36 patients (36eyes) with ROFD were retrospectively reviewed.All patients were operated on nasal sinus probing and open sinus surgery through transnasal endoscopic approach,and 10 patients underwent endoscopic optic nerve decompression.Results Seven patients had bilateral pansinusitis,9 patients had unilateral posterior ethmoidal sinusitis and sphenoiditis,8 patients had isolated sphenoiditis,8 patients had fungal sinusitis occured in the sphenoid sinus and unilateral posterior ethmoid sinus,3 patients had unilateral pyocyst and cyst of the sphenoid and ethmoid sinus,1 patient had frontal and ethmoidal sinusitis.All patients were confiemed by pathology after surgery.The visual acuity preoperative were as follows:3 eyes no light perception,10 eyes hand movement,11 eyes fingers counting less than 20 cm and 12 eyes were vision impaired in different degree.The visual acuity postoperative were as follows:3 eyes failed,13 eyes cured,20eyes improved from hand movement or fingers counting to fingers counting (30-60 cm).The efficiency rate was 91.7％(33/36).The other eye symptom was disappeared.Sinus epithelization was happened after surgery in all patients.Conclusions If the medicine expectant treatment is invalid,nasal sinus probing and open sinus surgery through transnasal endoscopic approach should be performed early in treatment of ROFD.Patients who suffered frnm severe visual damage and either unresponsive or intolerant to medical treatment should be administrated endoscopic sinus surgery including endoscopic optic nerve decompression.

Effective evaluation on treatment of allergic rhinitis with modified buzhongyiqi decoction / 国际中医中药杂志

Objective To evaluate effects of treating allergic rhinitis with modified Buzhongyiqi decoction.Methods 46 cases were randomly recruited into a control group and a treatment group according to random digit table.The treatment group was treated with Buzhongyiqi decoction,while the control group was treated with cetirizine.was After the treatment,the differences were assessed by comparing the disappeared time of clinical symptoms,symptom scores and cAMP、cGMP、IL-6、IL-8 immunological parameters ect,adverse reactions and morbid recurrence between the two groups.Results Compared with the control group,according to fisher test,the difference of clinical effect was statistically significant,the divergence of adverse reactions,iterating of illness were not statistically significant; the vanished time of clinical symptoms (t=3.32～4.48),symptoms scores (t=2.97),immune indexes (t=4.27～5.53)in the horizontal and vertical level were statistically significant (P＜0.05).Conclusion Buzhongyiqi decoction was suitable to treat allergic rhinitis.

Comprehensive research and evaluation of chlorogenic acid allergy / 中国中药杂志

<p><b>OBJECTIVE</b>The non-allergy of chlorogenic acid was demonstrated by the study result of allergy with different purity of chlorogenic acid and comprehensive analysis of literature.</p><p><b>METHOD</b>The allergies of different samples, which contained the different purity of chlorogenic acid extracts, chlorogenic acid for injection, interior solution of dialysis, external solution of dialysis, post-term chlorogenic acid for injection and chlorogenic acid for injection with degradation, were validated with active systemic anaphylaxis and passive cutaneous anaphylaxis on rats and guinea pigs respectively. The range of molecular weight of macromolecular remains after dialysis were identified by LC-MS.</p><p><b>RESULT</b>Allergic reactions were happened in dialysis isolated macromolecular substances, which were identified by LC-MS, and lower purity extracts (purity of chlorogenic acid < or = 40%), while the reactions were not happened in isolated micromolecular substances and high purity samples (purity of chlorogenic acid > or = 92%).</p><p><b>CONCLUSION</b>Macromolecules in lower purity of chlorogenic acid extracts were relative closely to the allergen causing anaphylaxis, but not the chlorogenic acid, which was demonstrated according to the study result and analysis of literatures home and abroad.</p>

Clinical analysis of 27 cases foreign body in hospital of otorhinolaryngology / 中国基层医药

Objective To discussing the cause and prevention of foreign body in hospital of Otorhinolaryngology.Methods Retrospectively aralyzed the cause and treatment of clinical data of 27 cases foreign body in hospital of Otorhinolaryngology,among which there are 13 csses in nose and nasal sinus,3 cases in cervix,2 in oesophagus,2 in mediastinum,2 in trachea,and 1 case in nose and pharynx antrum.Results Except for one failure of extracting foreign body in mediastinum and one failure of metal body in cervix,other 27 cases are all successful.But there are still 10 disputs between doctors and patients,causing bad influence in hospital.Conclusion To avoid the foreign body in hospital,our medical workers should strengthen our responsibilities,conclude our experience in season,improve our operating skills to prevent such things from happening in our work process.

E. coli-based production of recombinant HMG-17 and its antibacterial domain / 生物医学工程学杂志

Total RNA was extracted from human LAK cell, and a cDNA encoding mature peptide HMG-17 and its alpha helix domain was amplified by RT-PCR. The recombinant prokaryotic expression vector pGEX-1lambdaT-HMG-17 and pGEX-1lambdaT HMG-17alpha helix was constructed. Using affinity chromatography, thrombin cleaving and AU-PAGE elution, we obtained the purified HMG-17. Analyses of MIC, MEC and MBC indicated that HMG-17 and HMG-17alpha had strong antibacterial activity. MIC of the alpha-helic domain was almost the same as that of HMG17, suggesting that the alpha-helic structure would be essential for the antibacterial activity of HMG-17.