Two new sesquiterpenes in Qi-nan Aquilariae Lignum Resinatum / 中国中药杂志

This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan Aquilariae Lignum Resinatum by silica gel column chromatography, thin-layer chromatography, and semi-preparative high-performance liquid chromatography. One new elemane-type and one new eudesmane-type sesquiterpene compounds were isolated from the extract, and their structures were identified by MS, UV, IR, NMR, and ECD spectroscopic techniques, and named aquqinanol C(1) and aquqinanol D(2). Both compounds are novel compounds. The neuroprotective effect of the compounds on CORT-induced PC12 cell damage was determined in vitro. The results showed that compounds 1 and 2 exhibited a certain protective effect against CORT-induced damage in PC12 cells.

Clinical Study on Yiqi Yangxin Dingzhi Prescription for Anxiety State of Patients with Chronic Obstructive Pulmonary Disease / 中国中医药信息杂志

Objective To observe the effects of Yiqi Yangxin Dingzhi Prescription on anxiety state of patients with chronic obstructive pulmonary disease (COPD). Methods Randomized, parallel controled, single-blind research plan was used. Totally 80 patients with COPD were randomly divided into observation group and control group, with 40 cases in each group. Both groups received COPD stable maintenance treatment. On this basis, observation group was given Yiqi Yangxin Dingzhi Granules, while control group was given TCM simulator, one dosage per day, twice a day. The treatment lasted for two weeks both groups. TCM symptom scores, COPD assessment test (CAT) scores, and Hamilton Anxiety Scale (HAMA) scores before and after treatment in the two groups were observed. The safety indexes were monitored. Results Compared with before treatment, the TCM symptom scores, CAT scores, and HAMA scores of the two groups after treatment were significantly lower (P＜0.05). After treatment, the improvement degree of the TCM symptom total scores [(5.04±1.90) vs (2.27±1.83), the improvement degree of the CAT total score [(4.51±1.36) vs (1.81±1.47)], and the improvement degree of the HAMA total score [(5.32±2.78) vs (2.76±1.19)] in the observation group were better than the control group, with statistical significance (P＜0.05). No significant adverse events occurred in both groups. Conclusion Yiqi Yangxin Dingzhi Prescription can effectively improve the clinical symptoms of the patients with COPD and the life quality of the patients, and it has high safety.