RESUMO
Fourteen compounds were isolated from Dalbergia odoriferae and purified by repeated column chromatography on silica and sephadex LH-20 gel and structurally identified by spectral analysis. These compounds were identified as 4, 9-dimethoxy-3-hydroxypterocarpan (1), medicarpin (2), 2', 4', 5-trihydroxy-7-methoxyisoflavone (3), 2', 3', 7-trihydroxy-4'-methoxyisoflavan (4), formononetin (5), 3, 8-dihydroxy-9-methoxypterocarpan (6), koparin (7), 3-hydroxy-9-methoxypterocarp-6a-ene (8), 2'-hydroxyformononetin (9), stevenin (10), 2', 7-dihydroxy-4', 5'-dimethoxyisoflavone (11), lyoniresinol (12), 2, 4-dihydroxy-5-methoxy-benzophenone (13) and neokhriol A (14). Compounds 1, 3, 4, 6, 8, 12 and 14 were isolated from this plant for the first time. Antibacterial activity assay showed that compound 4 had inhibitory effect on Ralstonia solanacearum.
Assuntos
Anisóis , Química , Farmacologia , Antibacterianos , Química , Farmacologia , Benzofenonas , Química , Farmacologia , Cromatografia , Métodos , Dalbergia , Química , Dextranos , Géis , Isoflavonas , Química , Farmacologia , Testes de Sensibilidade Microbiana , Naftalenos , Química , Farmacologia , Extratos Vegetais , Química , Farmacologia , Pterocarpanos , Química , Farmacologia , Ralstonia solanacearum , Sílica GelRESUMO
AIM@#To study the chemical constituents of the whole plant of Chloranthus japonicus.@*METHODS@#Compounds were isolated and purified by column chromatography. Their structures were elucidated on the basis of spectroscopic methods.@*RESULTS@#Six sesquiterpenoids were obtained and their structures were identified as chlojaponilactone A (1), atractylenolide III (2), neolitacumone B (3), 10α-hydroxy-1-oxoeremophila-7(11), 8(9)-diene-8, 12-olide (4), shizukanolide C (5), and shizukanolide H (6).@*CONCLUSION@#Compound 1 is a new eudesmane-type sesquiterpenoid lactone, and compounds 3 and 4 have been isolated from this species for the first time.