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Objective To investigate the changes of matrix Metalloproteinases-9 (MMP-9) content in the cerebrospinal fluid of patients with brain injury and its clinical significance.Methods Sixty cerebrospinal fluid (CSF) specimens from patients with traumatic brain injury were chosen in our study as experimental group,and other CSF samples from 35 healthy subjects were selected as control group.The content of MMP-9 in cerebrospinal fluid was measured by enzyme-linked immunosorbent assay (ELISA) at 24 h and 72 h,1 and 2 weeks,respectively; and the comparative study was performed.Results The MMP-9 content in all CSF samples from the experimental group was significantly higher than that in the healthy control group (P＜0.05).Conclusion MMP-9 content in CSF of patients with brain injury increases obviously; MMP-9 in CSF may contribute to the severity of traumatic brain injury determination and guide the treatment strategies,which is worth for further study.
RESUMO
Objective To assess the clinical value of CT angiography (CTA) in early diagnosis of intracranial aneurysms. Methods Forty-two patients with subarachnoid hemorrhage suspected to arise from intracranial aneurysms underwent 64-slice spiral CTA followed by digital subtraction angiography (DSA). Chi-square test was employed to analyze the differences between the results by CTA and DSA. Results CTA confirmed the diagnosis of intracranial anenrysms (2-26 in diameter) in 39 patients, with suspected aneurysm in 1 patient and negative result in another. DSA identified intracranial anenrysms in 41 patients and showed negative result in 1 patient. The aneurysm detection rate showed no significant difference between CTA and DSA (X<'2>=0.263,P=0.608). Conclusion CTA can accurately diagnose aneurysm with diameter no less than 2 mm.