Analysis of fungal infection complicated with hemophagocytic lymphohistiocytosis in three children / 临床儿科杂志

Objective To improve clinically the recognition of fungal infection associated with hemophagocytic lymphohistiocytosis (HLH) in children. Methods Clinical data of 3 children with fungal infection complicated with HLH in our hospital was retrospectively analyzed. Results All the 3 cases complained of recurrent fever, 2 cases with cough and one case with vomiting. Hepatosplenomagaly and lymphadenectasis were found in the medical examination. The time of diagnosis of fungal infection through etiological examination was 5 days after admission. It was further diagnosed as hemophagocytic lymphohistiocytosis after failure of effective antifungal therapy. Routine blood test showed the counts of leukocytes were increased in early stage, while the number of platelets and hemoglobin decreased in different degrees. The recovery is not satisfactory using antifungal therapy alone, and 2 of them are gradually aggravated and treated with mechanical ventilation. On the basis of antifungal therapy, 2 cases were treated under HLH-2004 regimen, 1 received dexamethasone treatment. All the 3 cases received intravenous immune globulin, and showed improvement. Conclusions Fungal infection complicated with HLH in childhood is rare. The effect of simple antifungal therapy on the progression is limited. However, increasing immunosuppressive therapy based on effective antifungal therapy can improve the prognosis.

Application of the Mobile DR System in Large-scale Physical / 医疗卫生装备

Objective To discuss the application value of the mobile DR in large-scale physical examination. Methods Compared each 500 chest images that collected for the physical examination by the mobile DR, direct digital radiography(DR), then did another comparison about each 300 chest images of mobile DR and phnendoskiascope, recorded them by no displayed, displayed and limpid-displayed. Results The resolution of images collected by the mobile DR was comparative with the ones collected by direct digital radiography, better than phnendoskiascope in showing details. Conclusion The mobile DR images have a good resolution ratio as DR images have, meanwhile, this machine is easy to be taken and removed Examination while DR could not, and therefore the machine can do large-scale physical whatever inside or outside.