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Objective To evaluate the efficacy and safety of mometasone furoate dry powder inhalation(MF DPI) in treating mild and moderate asthma .Methods The databases of PubMed ,EMBASE ,CINAHL were retrieved .The randomized ,controlled trials(RCT) on mometasone furoate dry powder inhalation in treating mild and moderate asthma were collected .The quality evalua‐tion and the data extraction were performed according to the Cochrane systematic evaluation method .The RevMan 5 .0 .2 software was adopted for conducting statistical analysis .Results A total of 9 RCT involving 1 795 patients with mild and moderate asthma were included .The meta‐analysis results showed that MF DPI 200 mcg/d improved FEV1(MD=0 .24 ,95% CI:0 .17 -0 .30) ,am‐PEF(MD= 25 .25 ,95% CI:8 .18 -42 .32) ,pmPEF(MD= 16 .00 ,95% CI:2 .10 -29 .90);MF DPI 400 mcg/d improved FEV1 (MD=0 .32 ,95% CI:0 .25-0 .39) ,amPEF(MD=36 .44 ,95% CI:23 .82-49 .05) ,pmPEF (MD=28 .50 ,95% CI:14 .11-42 .89) , which suggested that MF DPI 200 mcg/d and MF DPI 400 mcg/d improving FEV1 ,amPEF and pmPEF was higher than the place‐bo ;for reducing patient′s early morning dyspnea and albuterol dose ,MF DPI 200 mcg/d and MF DPI 400 mcg/d were superior to placebo .For reducing patient′s early morning wheezing ,MF DPI 200 mcg/d and MF DPI 400 mcg/d were not superior to placebo . For the occurrence of adverse events ,there was no statistical difference between MF DPI 200 mcg/d and MF DPI 400 mcg/d with placebo(P>0 .05) .Conclusion The existing evidence indicates that MF DPI has higher effect and safety in treating mild and mod‐erate asthma .
RESUMO
The different types of penis thickening hydraulic filling materials have the advantage and disadvantage. The natural biological tissue material for own organization is convenient,avirulent,nonirritant,with good histocompatibility,without rejection,but has the transplant fat absorption,margin scar at donor site,and poor long-term appearance. Synthesized biological material silica gel phantom presented strong plasticity,could not affect by organism metabolism,absorption and degeneration,but had shortcomings,such as the feeling of foreign body,and skin infection. Varicosity polytetrafluoroethylene presented good histocompatibility,soft material,easy to be shaping,but high cost. The polyacrylamide hydrogel and the polymethyl acrylic acid methyl ester presented good histocompatibility,could not cause the immune response,easy to inject,but the shortcoming was easy to form the induration,but if had the complication to be very difficult to take out. Tissue engineered material was presently the key point in penis thickening research,but its research still occupied the start stage. The most reports were only at the laboratory stage. It requires some times for domestic application. This study summarized the penis thickening hydraulic filling materials,and analyzed the application of various filling materials in penis thickening technique.