RESUMO
Cholesterol is believed to be the major regulator involved in the formation and progression of atheroma plaque. Seaweeds are known to possess enormous biological activities. They contain variety of active constituents, which have pharmacological significance. The objective of this study is to explore hypolipidemic and hepatoprotective activities of the brown seaweed Iyengariastellata. Ethanolic extract of seaweed was suspended in distilled water and administered orally at 10mg/200g body weight to rabbits for 30 days and total lipid level, cholesterol, triglycerides, HDL, LDL, VLDL, alkaline phosphatase, SGPT, SGOT, Gamma GT were assessed. The results showed overall decrease in lipid profile whereas Iyengariastellata increased liver enzymes except SGPT which was decreased highly significantly, since SGPT is more specific indicator of liver injury, decreased value of SGPT indicates that Iyengariastellata toxicity is less severe and reversible with marked hypolipidemic effect, but during the course of ingestion of the seaweed the liver enzymes must be carefully monitored to ensure liver safety
Assuntos
Animais , Extratos Vegetais , Hipolipemiantes , Fígado , Colesterol , Alanina TransaminaseRESUMO
Several plants have been selected based on their use in traditional systems of medicine, and research has identified a number of natural compounds that could act as Nootropicagents. In this study a herbal product Intellan QvXmft% CenteHa asiatica, Bacopa monniera, Coriandum sativum, Amomum subulatum, Emblica officinalis and another product Cytacon [Cyanocobalamine] were selected The study was designed on animal models to explore the effects on different parameters. For this the animals were given chronic dosing for 6-8 weeks during and after which the parameters were observed to determine their effects. The purpose of focusing on such formulations is to do hematological screening in long-term use
The hematological parameter included hemoglobin/HCT, total leucocyte count, platelets. The lymphocytes and the monocytes counts were increased significantly by intellan, while cyanocobalamine increases RBC counts, platelet counts, monocyte counts, hematocrit etc significantly
The SGPT, SGOT were found increased in both of these drugs
RESUMO
Chamomile is considered as one of the oldest and also documented as medicinal plant. It has shown to be an anti-inflammatory, astringent and antioxidant especially in floral part since ancient times. Recent studies reported that chamomile has potential to lower blood sugar levels in hyperglycemia
In the present study we have investigated the pharmacological effects of chamomile tea on fasting and post prandial glucose levels and HbAlC in blood of diabetic rats [alloxan induced] and the results were compared with glibenclamide as standard. Statistical analysis was performed using SPSS. It has been observed in our study that it has reduced progressively the fasting and post prandial blood sugar levels, significantly in alloxan induced diabetic rats particularly on day 30and 60
It also reduced the level of HbAlC significantly at the end of the study and the effects were similar to that of the standard group
Chamomile tea administration has also controlled the reduction in weight in diabetic rats as compared to diabetic control and the results were not very much different from standard. Results from the present study indicate that chamomile tea have a glucose lowering effect in diabetic rats so its daily consumption can be potentially useful in hyperglycemia and it can be used as a substitute of conventional drug treatment. Further studies are necessary to elucidate the exact molecular mechanism involved in anti-diabetic action of chamomile