Hypoglycaemic effects of Andrographis paniculata Nees on non-diabetic rabbits.

So far known Andrographis paniculata Nees (AP) is a hepatoprotective, antiplatelet and antithrombotic drug. In this experiment its hypoglycaemic effect has been tried in various way. Water extract of AP 10 mg/kg body weight can prevent induction of hyperglycaemia significantly (P < 0.001) induced by oral administration of glucose 2 mg/kg body weight. But any how failed to do so in adrenaline induced hyperglycaemia. It also failed to demonstrate any "fasting blood sugar lowering effect" upon chronic administration (6 weeks) of AP. So probably AP prevents glucose absorption from gut. Whole experiment was done on rabbits.

Antifertility effect of andrographis paniculata in mice.

Antifertility effect of Andrographis Paniculata (AP) was observed in mice under different experimental conditions. When sun-dried powder of AP was mixed with animal's food (Rats Pelletts) in a dose of 2G per Kg. B.W. per day and was allowed to consume by the female mice daily for a period of six weeks, none of the animal (100%) were pregnant when mated with the male of proven fertility who did not receive the drug. On the other hand, the majority of the control female mice (95.2%) who did not receive the drug were pregnant when mated with the similar type of male as in the experimental group, and they continued to give birth to litters of usual size and number (average 5-6) for subsequent six matings.