RESUMO
Background: Recently natural products extracted from medical plants are very important in the field of alternative medicine. Glycosides, flavonoids and polyphenols are components of natural molecules have several health benefits such as anti-inflammatory, anti-oxidants, and have many ameliorative roles against male and female reproductive system intractable disorders. Objective of this study was to the compound of the plant extracts blend which is rich with glycosides, flavonoids and polyphenols was named as Ovatrine. The safety as well as the efficacy of some medical plants extracts on the fertility of the female mice was investigated using Ovatrine.Methods: Firstly, the safety of Ovatrine was evaluated using some mice and the levels of the follicle stimulating hormone in the serum of the treated animals with Ovatrine was evaluated using biochemical tests. Also, the effects of the Ovatrine on the histological parameters of the treated ovary and uterus were evaluated using histological analysis.Results: The animals treated with Ovatrine were healthy and did not show any signs of mortality, toxicities and there were no blood contents changes. Additionally, follicle stimulating hormone level in the serum increased after administration with Ovatrine twice a day for 30 days as compared with the non-treated animals. Furthermore, the histological structures of the ovary and uterus improved in the mice treated with Ovatrine compared with that in the non-treated mice.Conclusions: In general glycosides, flavonoids and polyphenols, which were found in the Ovatrine in a higher concentration, have important health benefits such as antioxidant, anti-inflammatory and improve the fertility in the female mice. In the future this study will be very important for drug development which composed mainly from safe natural products and used for infertility and intractable diseases treatment.
RESUMO
Background: Flavonoids and polyphenols are groups of natural substances have variable phenolic configurations, many benefits as anti-inflammatory and anti-oxidants, and have many protective roles against male reproductive system disorders. Objective of this study was to study the safety as well as the efficacy of a blend from some plants extracts with precise ratios and rich with flavonoids and polyphenols named in this study as “Manfort” on the safety, fertility, and testicular histology in the male mice.Methods: Firstly, some mice were used to evaluate the safety of Manfort and the levels of the testosterone in the serum of the treated animals with Manfort using biochemical analysis. Also, the efficacy of the Manfort on the histological architectures of the treated testis was evaluated using histological techniques.Results: The mice treated with Manfort did not show any signs of mortality, toxicities and blood contents changes. Furthermore, testosterone levels in the serum elevated after administration with Manfort twice a day for 21 days compared with the non-treated mice. Additionally, the histological structures of the testis improved in the mice treated with Manfort compared with that in the non-treated animals.Conclusions: In general flavonoids and polyphenols, which were found in the Manfort diet in a large amount, have important role in as antioxidant, anti-inflammatory and improve the fertility in the male mice. In the future these data might be very important to manufacture a drug composed from safe natural products for infertility and intractable diseases treatment.