1.
Trop. j. pharm. res. (Online)
;
(2): 197-206, 2003.
Artigo
em Inglês
| AIM
| ID: biblio-1273054
RESUMO
"In this note we describe a modification of the sequential probability ratio test (SPRT) developed for the purpose of ""flagging"" a significant increase in the mortality rate of a treatment relative to a control while ensuring that double-blinding and the Type I error for the primary test of efficacy; also based on mortality rates; is not compromised."