Studies on the Antivacterial Effect of Cephalosporin Derivatives / 대한피부과학회지

The minimal inhibitory concentration(MIC) of cephalosporin derivatives, (cephaloridine, cefazolin sodium, cephradine, cephapirin aodium, cephacetrile sodium, and cephalexin from various Korean drug companies) for Staphykcoccus aureus ATCC 25923 and Escherichia coli ATCC 25922 was measured by the tube dilution method, using Mueller-Hinton broth. The results obtained were as follows: 1) The MIC of each individual cephalosporin derivative, although produced by different manufacturers, was similiar or equal. 2) Against Staphyloeoccus aureus, cephaloridine and cephapirin had the lowest MIC while cephradine and, cephalexin the highest. Against E. coli, cephaloridine and cefazolin had the lowest MIC while cephradine and cephalexin the highest. 3) The MIC against Staphylococcus aureus was l5.6 to 250 times lower than that against E. coli in all cephalosporin derivatives. 4) The MIC against Staphylococcus aureus ranges from 0.0125 to l.0ug/ml and against E. coli from 1. 56 to 25ug/ml in all cephalasporin derivatives.

A 10 Year Period (1968 - 1977) of Clinical Observation of Cutaneous Malignant Tumors / 대한피부과학회지

From january 1968 to Septomber 1977(approximately 10 years) the authors clinically observed 105 cases of malignant curaneous tumors that visited the Department of Dermatology at Chon-nam University Hospital. The results obtained can be summarized as follows: 1) The incidence of curaneous malignat tumors versus the total number of outpatients visitiong the Department of Dermatology was 0.33 2) The age of onset was quite varied but the majority of cases, 71 cases(67.62%), were over 50 years old. #) The ratio of men to women was 1.56:1. 4) Among the 105 cases of malignant cutaneous tumors the most frequently observed type was squamous cell carcinoma, 40 cases(40.0%) The next most frequent rypes were basal cell carcinoma, 19 cases (18.10%) and malgnant melanoma, 12cases(11.43%) 5) The most common predilection sites were the head and neck in which 55cases(52.38%) were observed. Among these cases the face was most commonly affected, 40 cases(38.10%). The predilection sites of the basal cell carcinoma cases were the nose(47.37%), cheek(21.04%) and eyelid(15.79%). Those of the squamous cell carcinoma cases were the lower lip(26.90%), cheek(24,43) and penis(14,29%). Finally that of the malignant melanoma was the plantar surface(58.34%) 6) We observed metastasis only in wquamous cell carcinoma, Among the 42 cases of squamous cell carcinoma seen, I1 cases showed metastasis, Among these I1 cases of metastasis, 9 cases were metastajzed into the regional lymphnodes, and in 3 cases methstsis to the lung was demonstracted. 7) We found no relationship between the presence of a particular kind of original skin lesion or injury and the development of a cutaneous malignant tumor. some original lesions related to the curaneous malignant tumors we mentosem, radiation, sporotrichosis, neurofibromatosis, etc. 8) One or more of the four following methods of treatment were used on 19 of the observed cases: 1) Surgical Operation 2) Irradiation Therapy. 3) Electrosugery, 4) Chemotherapy, In seven cases(Basal cell carcinoma 5 cases, Squamous cell carcinoma 2 cases) a complete cure was seen, while in five cases(Kaposi's sarcoma 1, case Squamous cell carcinoms 4 cases) the curaneout maligant tumor recurred No improvement was demonstrated in two (Squamous cell carcinoma 1 case, Malignant melanoma 1 case) of the cases and in four cases(Squamous cell carcinoma 3 cases, Malignant Melanoma 1 case) no prognosis could be made because the patients did nor retum to the clinic to complete treatment.