Detectability of Hepatocellular Carcinoma: Comparison of Gd-DT PA-Enhanced and SPIO-Enhanced MR Imaging

PURPOSE: To compare the detectability of hepatocellular carcinoma (HCC) using superparamagnetic iron oxide (SPIO)-enhanced T2-weighted turbo spin echo (TSE), SPIO-enhanced T2*-weighted FISP, and dynamic Gd-DTPA-enhanced fast low-angle shot (FLASH) MR images. MATERIALS AND METHODS: In order to assess their hepatic lesions, 25 patients (20 men and 5 women) with HCC were enrolled in an MR study in which both gadolinium and SPIO were used. Since the lesions were most conspicuous during the phase of dynamic arterial dominant phase of dynamic gadolinium-enhanced imaging, this was the phase used for analysis. Images were analyzed qualitatively and quantitatively, and to compare the diagnostic value of gadolinium-enhanced imaging with that of SPIO-enhanced imaging for the detection of HCCs, a receiver-operated characteristic curve was obtained. RESULTS: Qualitative analysis revealed a significantly higher percentage of signal loss and a higher liver-lesion contrast-to-noise ratio on SPIO-enhanced FISP imaging than on SPIO-enhanced T2-weighted TSE imaging (p<0.05). It also showed that the lesions were most clearly visible on SPIO-enhanced FISP imaging(and signifi-cantlyso), followed by SPIO-enhanced T2-weighted TSE imaging, and dynamic gadolinium-enhanced imag-ing. Imaging artifacts were more prominent on SPIO-enhanced T2-weighted TSE than on SPIO-enhanced PISF imaging or dynamic gadolinium-enhanced imaging(p<0.05). According to ROC analysis, SPIO-enhanced T2-weighted turbo spin echo(TSE) or SPIO-enhanced FISP imaging achieved higher accuracy than did dynamic gadolinium-enhanced FLASH imaging(p<0.05). CONCLUSION: For the detection of hepatocellular carcinomas, SPIO-enhanced MR imaging is better than gadolinium-enhanced FLASH imaging.

Diagnosis of Acute Appendicitis in the Community Hospital: Validity and Usefulness of Sonography

PURPOSE: To compare the accuracy of initial clinical diagnosis with that of ultrasonography(US) in diagnosingappendicitis and to determine its effect on the care of patients in a community hospital. MATERIALS AND METHODS: One hundred and fifty patients with suspected appendicitis were prospectively examined with US. Prior to this,they had been divided into three groups on the basis of clinical judgement regarding diagnosis and their treatmentplan: Group I : high suspicion (probability > 75%) - urgent surgery indicated ; Group II : equivocal (probability25 - 75%) - in hospital for observation, Group III : very unlikely (probability < 25%)- discharge without furthertesting. In order to determine the validity of these groupings, we calculated the sensitivity, specificity, andaccuracy of sonographic examination, and the likelihood ratios of initial clinical diagnosis. RESULTS: USrevealed a sensitivity of 92%, specificity of 90%, positive predictive value of 95%, negative predictive value of85% and overall accuracy of 91%. The initial clinical impression showed a sensitivity of 70%, specificity of 82%,positive predictive value of 89%, negative predictive value of 58%, and overall accuracy of 74%. Among 79 patientsin the high clinical risk category (Group I), the sensitivity, specificity and accuracy of US were 96%, 89%, and95%, respectively. Among 71 patients in the low- and intermediate- clinical categories (Groups II and III), thesensitivity, specificity, and accuracy of US were 83%, 90%, and 87%. The likelihood ratios were 3.9 in Group I,0.52 in Group II, and 0.15 in Group III. In 32 of 150 patients (21%), the findings of US led to changes in theproposed management plan. CONCLUSION: The overall accuracy of US in the diagnosis of appendicitis wasstatistically superior to that of the clinician's initial impression (p<0.05). In addition, US played an importantrole in making decisions regarding the treatment plan.

Aneurysmal Malformation of the Extrahepatic Portal Vein: A Case Report

Aneurysmal malformation of the portal vein is a rare entity. To our knowledge, only scattered reports ofportal vein aneurysms appear in the literature in English, and there is no previously published report in Korean.We describe a case exhibiting aneurysmal malformation of the extrahepatic portal vein at the hepatic hilum; thefindings demonstrated by ultrasound, CT and angiography are discussed, a review of previously described cases isincluded.

Bronchial Arterial Embolization for Hemoptysis: Analysis of Outcome in Various Underlying Causes

PURPOSE: To clarify the short-term effect and long-term results of bronchial arterial embolization forhemoptysis in three groups with tuberculosis, idiopathic bronchiectasis and lung cancer. MATERIALS AND METHODS:This study invo l ved 54 patients who underwent arterial embolization for the control of hemoptysis. Among 54, thecauses of hemorrhage were; pulmonary tuberculosis(n=32), idiopathic bronchiectasis (n=15), and lung cancer(n=7).In all patients, em-bolization was performed using Gelfoam particles and three underwent additional coilemboliza-tion. After the procedure, patients were followed up for between 1 and 95 (mean, 36.7) months. Short-termresults were assessed on the basis of careful observation of patients for 1 month after ar-terial embolization andwere classified as either; successful, indicating complete cessation of he-moptysis for 1 month, or failed,indicating continuing hemoptysis or recurrence within 1 month. Long-term results were evaluated in patients inwhom the procedure was successful in the short term and who could be followed up for at least 6 months. Patientsshowed either complete remis-sion(CR), indicating complete cessation of bleeding during the observation period;partial remis-sion(PR), indicating complete cessation of hemoptysis with recurrent bloody sputum during theobservation period; or recurrence, indicating recurrent hemoptysis, and were grouped accordingly. RESULTS: Noserious procedure related complications occurred except for mild chest pain or fever, of which showed spontaneousrelief within a few day s. The overall short-term success rate was 7 9 .6 %(43/54); individual rates were 84.4%for pulmonary tuberculosis (27/32), 80% for idiopathic bronchiectasis (10/15), and 57.1 % for lung cancer (4/7).Long-term follow-up showed that complete remission was achieved in 24 of 43 cases (55.8 %).The respectivelong-term remission and recur-rence rates were 75 % and 25 % for bronchiectasis, 70.4 % and 29.6 % for pulmonarytuberculosis. While four lung cancer patients whose initial outcome was successful showed no recurrence ofhe-moptysis, three died within 3 months of embolization. CONCLUSION: Embolization of bronchial arteries using aGelfoam sponge is effective as initial treat-ment for moderate or severe hemoptysis caused by benign disease.During long-term follow up, high remission rates were achieved in pulmonary tuberculosis and idiopathicbronchiectasis pa-tients, while the shortest bleeding control was in cases involving lung malignancy.

Percutaneous Cholecystostomy for Gallbladder Perforation: Early Response and Final Outcome in 10 Patients

PURPOSE: To evaluate the efficacy of percutaneous cholecystostomy (PC) as a therapeutic maneuver for patientswith spontaneous gallbladder (GB) perforation. MATERIAL AND METHODS: Ten patients with acute cholecystitis andsuspected GB perforation underwent emergency PC; perforation was documented by means of ultrasound, computedtomography, and/or fluoroscopy. All patients but two had a variety of high risk factors for open cholecystectomy:diabetes mellitus (n=2), cardiac disease (n=2), acute renal failure (n=1), liver cirrhosis (n=1), overwhelmingsepsis (n=1), and age over 80 (n=1). All percutaneous cholecystostomies were performed with ultrasound guidanceand preferably via the transhepatic route. A favorable response to PC was defined as an improvement in clinicalsymptoms and signs or reduction in fever, and return of the WBC to normal within 72 hr of the procedure. RESULTS:All procedures were technically successful, and no major procedure-related complications occurred. Eight patients(80%) responded favorably to PC. One, who did not respond, underwent emergency cholecystectomy next day due toworsening peritonitis, and the other who failed to respond within 72 hr showed delayed response after drainage ofa coexistent liver abscess at seven days after the procedure. A patient who responded to PC experienced catheterdislodgement four days after the procedure but reinsertion was not required. Five of eight patients who respondedpositively underwent elective cholecystectomy after the improvement of clinical symptoms, and the three remainingpatients improved without further surgery. CONCLUSION: For the treatment of patients in whom GB perforation issuspected, PC is a safe and effective alternative to surgical cholecystectomy.