Measurement and Analysis of Serous Fluid in Central Serous Chorioretinopathy using OCT

PURPOSE: To evaluate the correlation between the degree of serous fluid and best corrected visual acuity at the first visit in central serous chorioretinopathy using optical coherence tomography. METHODS: Retrospective analysis was performed for 30 eyes of 30 patients with central serous chorioretinopathy. Cross-sectional retinal images through the center of the fovea were obtained from all eyes by optical coherence tomography. The height, sectional area, and the tangent of theta (tan theta) were estimated. They were statistically analyzed and correlated with best corrected visual acuity. RESULTS: Mean (+/-SD) height of serous fluid was 341.40+/-120.60 micrometer, mean (+/-SD) sectional area was 0.55+/-0.29 mm2, and mean (+/-SD) tan theta was 0.22+/-0.04. The correlation coefficients between best corrected visual acuity at the first visit and sectional area were r=-0.740 (P=0.001). CONCLUSIONS: Optical coherence tomography is useful for the quantitative evaluation of serous neurosensory retinal detachment and estimating visual acuity in central serous chorioretinopathy.

A Case of Anterior uveitis Following Influenza Vaccination

PURPOSE: To report one case of anterior uveitis following influenza vaccination in immunecompromised patient. METHODS: A 63-year-old woman with anterior uveitis following influenza vaccination 9 days after ovarian cancer chemotherapy was examined systematically and treated with 1% prednisolone eyedrop and dexamethasone subconjunctival injection. RESULTS: At the first visit, the corrected vision and intraocular pressure were 0.3 and 23 mmHg in both eyes. And, corneal edema and inflammatory cells in anterior chamber and vitreous were found, but there was no abnormal finding in fundus photography, fluorescein angiography and systemic evaluation. Although the response to steroid treatment was slow, she got better ophthalmologically and no problem in follow checkup 6 months later. CONCLUSIONS: We report a case of anterior uveitis following influenza vaccination in an immunocompromised patient after chemotheraphy and recommend to be cautious in influenza vaccination in the suspicious case of immunecompromized state.

Correlation between Retinal Nerve Fiber Layer Thickness and Visual Field in Normal Tension Glaucoma Patients

PURPOSE: To determine the correlation between retinal nerve fiber layer (RNFL) thickness and visual field defect for early detection of normal tension glaucoma (NTG). METHODS: Sixty eyes newly diagnosed with NTG and 50 normal eyes were analyzed by optical coherence tomography and a short wave length automated perimetry test. The relationship between RNFL, divided into 12 areas, and visual field, divided into 21 areas, were analyzed. RESULTS: Sixty eyes that revealed visual field defect by SWAP showed thinning of the RNFL. OCT sectors 6-o'clock, 7-o'clock, and 8-o'clock (inferior and inferotemporal) and SWAP visual field zones 13, 14, 15 and 16 (superior paracentral, arcuate areas, and the nasal step) were the most frequently damaged. The strongest associations were between the inferior and inferior temporal RNFL sectors 6, 7, and 8-o'clock and the superior nasal/arcuate visual field zones 13, 14, and 15 (R2 range=15.9-34.6%, all p<0.05). CONCLUSIONS: A combination of these two methods may be helpful for the early detection of NTG.