Comparison of Nutrient Intake and Diet Quality Between Hyperuricemia Subjects and Controls in Korea

Hyperuricemia is associated with metabolic syndrome as well as gout, and the prevalence of hyperuricemia is increasing in Korea. This study aimed to compare the nutrient intake and diet quality between hyperuricemia subjects and controls. Of the 28,589 people who participated in a health examination between 2008 and 2011, 9,010 subjects were selected whose 3-day food records were available. Clinical and laboratory data were collected from electronic medical records. Diet quality was evaluated using the food habit score (FHS), nutrient adequacy ratio (NAR), and mean adequacy ratio (MAR). The prevalence of hyperuricemia was 13.8% (27.1%, men; 5.2%, women). Body mass index, waist circumference, triglycerides, total cholesterol, and low-density lipoprotein cholesterol were significantly higher (p < 0.0001), while high-density cholesterol (p < 0.001) was significantly lower in the hyperuricemia subjects than in the controls. The hyperuricemia subjects had a lower intake of vitamin A (p < 0.004), vitamin C, folate, fiber, and calcium than the controls (p < 0.0001). Intake of vegetables and dairy products was significantly lower, whereas alcohol intake was significantly higher in the hyperuricemia subjects than in the controls ( p < 0.0001). The FHS (p < 0.0001), MAR (p < 0.0001), and NARs for vitamin A (p = 0.01), vitamin B2, vitamin C, folate, and calcium (p < 0.0001) were significantly lower in the hyperuricemia subjects than in the controls. In conclusion, the hyperuricemia subjects reported poorer diet quality than the controls, including higher alcohol intake and lower vegetable and dairy product intake.

Progressive Multifocal Leukoencephalopathy in a Patient With Myasthenia Gravis and Thymoma

Progressive multifocal leukoencephalopathy (PML) is a rare and fatal disease caused by JC virus. We report a case of PML which developed in a 61-year-old female patient with myasthenia gravis (MG) and thymoma. After 6 years of immunotherapy and chemotherapy she presented with hand weakness followed by progressive decline of consciousness. Serial brain MRI showed rapidly progressive multifocal white matter changes. The JC virus DNA was detected on cerebrospinal fluid. This is a third report of PML in MG.

Propofol Infusion Syndrome in a Patient with Epilepsia Partialis Continua

Propofol has been used for the treatment of refractory status epilepticus, but propofol can cause propofol infusion syndrome (PRIS). PRIS is rarely developed and often fatal. The syndrome is characterized by metabolic acidosis, rhadomyolysis, and cardiac failure. Most reports were described in critically ill patients undergoing long-term propofol infusion at high doses. But many systemic confounding factors are mixed with the fatality of PRIS and there are no report on epilepsia partialis continua which has stable systemic conditions. We report PRIS in a patient with epilepsia partialis continua.

Propofol Infusion Syndrome in a Patient with Epilepsia Partialis Continua / 대한간질학회지

Propofol has been used for the treatment of refractory status epilepticus, but propofol can cause propofol infusion syndrome (PRIS). PRIS is rarely developed and often fatal. The syndrome is characterized by metabolic acidosis, rhadomyolysis, and cardiac failure. Most reports were described in critically ill patients undergoing long-term propofol infusion at high doses. But many systemic confounding factors are mixed with the fatality of PRIS and there are no report on epilepsia partialis continua which has stable systemic conditions. We report PRIS in a patient with epilepsia partialis continua.

Malignant Mesothelioma Presenting as Large Neck Mass / 결핵및호흡기질환

Malignant mesothelioma is the most common primary malignant tumor involving pleura, but its diagnosis is difficult to determine by pathology in addition to the fact that it is rare. We present an unusual case of malignant mesothelioma, which initially presented as large neck mass contrary to the more common presentation of a rind like growth along the pleura demonstrated on imaging and by pathologic findings.

Intracoronary Stent Deployment without Antiplatelet Agents in a Patient with Idiopathic Thrombocytopenic Purpura

Deciding on the appropriate antiplatelet therapy is a challenge when treating patients with idiopathic thrombocytopenic purpura (ITP) and who are undergoing percutaneous coronary intervention (PCI). We describe here a case of PCI in a patient with chronic, refractory ITP. A 61-year-old woman presented with exertional chest pain and a low platelet count (4 x 109/L) at admission. Coronary angiography revealed 99% stenosis of the mid left anterior descending artery and 95% stenosis of the mid left circumflex artery. Antiplatelet agents couldn't be administered because of the risk of bleeding. After transfusion of platelets and administering intravenous immunoglobulin, we deployed baremetal stents in both lesions without administering any antiplatelet agents. Although focal in-stent restenosis developed 5 months later, there was no episode of stent thrombosis despite not using antiplatelet agents. The present case suggests that the rate of stent thrombosis may be lower was previously thought and antiplatelet therapy may be considered on a case by case for patient suffering with thrombocytopenia.

A Case of Reversal of Takotsubo Cardiomyopathy in Patient with Pheochromocytoma

'Takotsubo cardiomyopathy' or 'stress-induced cardiomyopathy' is a newly described clinical entity characterized by transient left ventricular apical ballooning and left ventricular apical dyskinesis in the absence of angiographic feature of significant coronary artery disease. The cause of takotsubo cardiomyopathy is unclear, but catecholamines probably play a role in the takotsubo cardiomyopathy. We report a case of pheochromocytoma-induced takotsubo cardiomyopathy that showed atypical pattern of reversed takotsubo cardiomyopathy with transient significant mitral regurgitation. This is the first case showing the reversal of takotsubo cardiomyopathy due to pheochromocytoma in Korea.

The Effect of Cutting Balloon Angioplasty on Vascular Access Dysfunction in Hemodialysis Patients / 대한신장학회잡지

BACKGROUND:When angioplasty is performed using conventional balloon to treat arteriovenous fistula stenosis, treatment failure frequently occurs in case stenosis is very seve or tight. Cutting balloons were made to overcome these disadvantages. The purpose of this study is to evaluate the clinical effectiveness of cutting balloon angioplasty (CBA). METHODS:Twenty-four patients treated with CBA were included in this study. We evaluated clinical signs of venous stenosis, fistulographic findings, indications of CBA, procedure outcomes, and its complications. RESULTS:Out of the total 24 patients, the most common indication for fistulogram was increased negative arterial pressure (n=8). The stenotic lesions were juxta-anastomotic vein (n=19), graft-venous anastomosis (n=3), artery-venous anastomosis (n=1), and axillary vein (n=1), retrospectively. Conventional angioplasty had been attempted but failed in all 24 patients who were treated with CBA. The initial success rate of CBA was 100%, and the follow-up patency rate at 6, 12, 24 month after the procedure were 73.1%, 65.8%, and 49.3%, respectively. Procedure- related complications were minimal leakage of contrast media (n=3), partial rupture of vessel wall (n= 3), and vessel dissection (n=2). Three partial ruptures and one severe dissection were successfully treated only with balloon inflation without surgical operation. And leakages and one mild dissection spontaneously improved without specific treatment. CONCLUSION:This study suggests that cutting balloon angioplasty is relatively safe and effective in treating failed stenotic lesions when compared with conventional angioplasty in hemodialysis patients.

A Case of Osmotic Demyelination Syndrome after Hemodialysis Treatment in a Uremic Patient with Severe Hyperosmolality / 대한신장학회잡지

Osmotic demyelination syndrome (ODS) is a distinctive clinical syndrome with characteristic MR features in the central pons (central pontine myelinolysis) and in other brain locations (extrapontine myelinolysis). Rapid correction of hyponatremia is associated with ODS, but hyperosmolality rarely causes it. Here we report a case of ODS developed in a hemodialysis patient with severe uremia and concomitant hyperosmolality. A 67-year-old male was presented with general weakness and dyspnea. Laboratory findings showed severe uremia (blood urea nitrogen, 167 mg/dL; serum creatinine, 15 mg/dL), hyperosmolality (336 mOsm/kg H2O), and normal range of sodium (145 mEq/L). After the first hemodialysis treatment, his consciousness was changed to lethargic state. We initially suspected dialysis disequilibrium syndrome, but the symptoms were aggravated. MRI showed edema in central pons and symmetrical extrapotine lesions in the subcortical white matter, lateral thalamus, and posterior capsule, consistent with ODS. In spite of aggressive measures including continuous renal replacement therapy, he died of sepsis at the 26th hospital day.

A Case of Central Vein Stenosis in a Hemodialysis Patient with History of Humerus Osteomyelitis Ipsilateral to Arteriovenous Fistula / 대한신장학회잡지

Central vein stenosis (CVS) is a serious complication in hemodialysis patients mostly related to central vein catheterization. Although rare, CVS may also develop without any previous history of central venous catheterization. Here we report a case of central vein stenosis in a hemodialysis patient with the history of humerus osteomyelitis ipsilateral to arteriovenous fistula. The patient did not have any previous history of central vein catheterization. She received radial artery-cephalic vein fistula operation for maintenance hemodialysis. Venography was performed because of inadequate vein maturation 2 months after the operation. Venography shows complete occlusion of left innominate vein, multiple collateral veins and backflow of left internal jugular vein. After percutaneous transluminal angioplasty with stent insertion, the innominate vein was fully dilated and the collateral vessels completely disappeared.

A Case of Hemichorea of Unknown Cause in a Hemodialysis Patient / 대한신장학회잡지

Uremic patients undergoing hemodialysis (HD) therapy are prone to develop encephalopathy, but the cause is often unclear. Clinical signs of encephalopathy in the uremic patient often overlap with several other affections causing neurological disorders. Chorea or hemichorea occurs very rare, when basal ganglia are injured in HD patients. We hereby report a case of hemichorea of unknown cause in a hemodialysis patients. A 57-year-old diabetic HD patient was presented with sudden onset of right hemichorea. We could not find causes of hemichorea such as hyperglycemia, hepatic failure, drug, hyponatremia, and thiamine deficiency. T1-weighted MRI demonstrated hyperintense lesion limited to the left basal ganglion. Hemichorea disappeared completely 6 months after the onset with support care.

The Role of the Epidemiological Causality of the Association between Smoking and Lung Cancer / 한국역학회지

It is generally accepted that acknowledgment of the causality of the association between smoking and lung cancer plays a crucial role in imposing liability on tobacco manufacturers in tobacco-related cases. However, acknowledgment of the epidemiological causality of the association is merely a precondition to putting liability on tobacco manufacturers; it does not play a crucial role. Smokers smoke manufactured tobacco by their right to choose according to their self-decision; therefore, it is not reasonable to place all liability concerning lung cancer on tobacco manufacturers. This paper studies the dual structure of the causality of the association between tobacco manufacturing and smoking as well as smoking and lung cancer. It can be understood that tobacco manufacturers must be held liable for lung cancer caused by smoking when there was intentional concealment or insufficient provision of information on the harmfulness of tobacco and the addictiveness of nicotine. The epidemiological causality of the association is the minimum scientific and legal precondition to placing liability on tobacco manufacturers for lung cancer caused by smoking. However, striving for protection and promotion of national health by, for instance, promoting antismoking programs, the epidemiological causality of the association adequately plays a social role when viewed from a public health perspective.

A study on correlations between tongue with skeletal pattern and intermaxillary space in Class II malocclusion adult patients / 대한치과교정학회지

This study was designed to evaluate the correlations between tongue with skeletal pattern and intermaxillary space in Class II malocclusin adult patients. Craniofacial skeletal pattern was analyzed on the lateral cephalometric radiograph and the subjects were divided two groups by facial ratio, the 30 subjects of hyperdivergent group and the 30 subjects of hypodivergent group. The size and posture of tongue and intermaxillary space were measured on the lateral cephalometric radiograph. These data were statistically analyzed to examine significant differences between both groups and compared the correlation between tongue with skeletal measurements and intermaxillary space in each group. The results of the study were as follows. : 1. In comparison of th tongue and intermaxillary space, the measurement of TS/IS showed significantly larger in hyperdivergent group and PIH and IS showed significantly larger in hypodivergent group. There were no statistically significant differences in the measurements of the height and posture of tongue. 2. In correlation between tongue with craniofacial skeletal measurements, the length and height of tongue showed the highest correlation with AFH(anterior facial height) in both groups(p<0.011). And that measurements showed high correlation with PFH(posterior facial height) in hypodivergent group. 3. In both groups, most measurements of tongue showed high correlation with intermaxillary space and the height and space of tongue showed high correlation with AIH and PIH(p<0.01).