RESUMO
Dermatofibroma is a fibrohistiocytic tumor of the skin that commonly occurs as a solitary lesion on the lower extremities of young women. Multiple eruptive dermatofibromas (MEDFs), defined as the presence of 5 to 8 dermatofibromas appearing within a period of 4 months, are rare, and the etiology of MEDFs remains unknown. However, MEDFs are frequently thought to be associated with altered immunity, such as autoimmune diseases and immunosuppression. It is unclear why MEDFs occur in association with these conditions, but this relationship may suggest that MEDFs are the result of an abortive immunoreactive process. We herein describe a middle-aged woman who developed multiple dermatofibroma. She had myasthenia gravis for 8 years, and developed MEDFs after undergoing oral corticosteroid treatment (245 mg/week) for 3 months. Therefore, our case suggests that the use of immunosuppressants is a more dominant factor for the development of MEDFs than underlying autoimmune diseases.
Assuntos
Feminino , Humanos , Doenças Autoimunes , Histiocitoma Fibroso Benigno , Terapia de Imunossupressão , Imunossupressores , Extremidade Inferior , Miastenia Gravis , PeleRESUMO
BACKGROUND: Kaposi varicelliform eruption (KVE) is a disseminated viral infection primarily caused by the herpes simplex virus in the setting of an underlying chronic skin disease. Few studies have reported the clinical characteristics and predisposing factors for recurrent KVE.OBJECTIVES: To characterize the clinical features and predisposing factors for recurrent KVE.METHODS: This retrospective comparative study of recurrent vs. single-episode KVE was performed at the Pusan National University Hospital between 2004 and 2017.RESULTS: A total of 84 episodes occurred in 60 patients, and of these, 13 patients developed recurrence (21.7%). No statistically significant intergroup difference was observed in the mean age and sex distribution. The face was the most common site of involvement in both groups, followed by the trunk and the upper and lower extremities. Atopic dermatitis was the most common pre-existing disease in both groups; however, Darier's disease was more common in the recurrent KVE group, and this difference was statistically significant. Most patients with KVE (66.7%) showed aggravation of the underlying skin disease within 3 months of KVE onset. This finding was more prominent in patients with recurrent episodes (91.7%) than in those with single-episode KVE (58.3%), (p=0.040).CONCLUSION: This study can contribute to a better understanding of recurrent KVE and guide clinicians in treating patients with conditions predisposing to KVE.
Assuntos
Humanos , Causalidade , Doença de Darier , Dermatite Atópica , Erupção Variceliforme de Kaposi , Extremidade Inferior , Cobertura de Condição Pré-Existente , Recidiva , Estudos Retrospectivos , Distribuição por Sexo , Simplexvirus , DermatopatiasRESUMO
PURPOSE: A pertussis patient from an elementary school, in Gyeonggi Province, Korea, was notified to public health authority on July 25, 2017. Epidemiologic investigation was conducted to identify the magnitude, possible source of infection and risk factors for this outbreak on August 17, 2017. MATERIALS AND METHODS: A case was defined as the school student experiencing cough for more than two weeks with or without paroxysmal, whoop, or post-tussive vomiting. Control was defined as the student polymerase chain reaction-negative at the school. School based surveillance was implemented to identify additional cases. RESULTS: From June 29 to August 27, 2017, nine patients of pertussis were identified from an elementary school. Among nine cases, eight were confirmed by polymerase chain reaction positive. All cases had cough, one (11%) had post-tussive vomiting, and one (11%) had fever. Eight cases had macrolide for 7 days in outpatient clinic, and one case admitted in a hospital. There was no significant difference of demographic factors including gender (p=0.49), age group (p=0.97), number of series of vaccination of pertussis (p=0.52), the number of participation of after school activity (p=0.28), and the time elapsed since last vaccination (p=0.42). However, we found the history of contact within the classroom or after-school activity was only the independent risk factor among all the demographic factors collected (odds ratio, 63.61; 95% confidence interval, 4.35 to 930.79). CONCLUSION: The contributing factor for transmission is associated with the case-contact. Immediate identification of pertussis with use of appropriate diagnostic test may help to avoid a large number of cases.
Assuntos
Humanos , Instituições de Assistência Ambulatorial , Estudos de Casos e Controles , Tosse , Demografia , Testes Diagnósticos de Rotina , Surtos de Doenças , Febre , Coreia (Geográfico) , Reação em Cadeia da Polimerase , Saúde Pública , Fatores de Risco , Vacinação , Vacinas , Vômito , CoquelucheRESUMO
No abstract available.
Assuntos
Dermoscopia , Cabelo , Hamartoma , Hipertricose , Músculo LisoRESUMO
Unilateral linear capillaritis (ULC) is a rare variant of pigmented purpuric dermatosis (PPD). ULC is clinically characterized by unilateral linear macules on the lower extremities, which fade spontaneously. We present three patients with linearly distributed purpuric macules on only one side of the lower extremities. Skin biopsy showed histopathological features of PPDs. We diagnosed ULC based on these clinicopathological findings. For all patients, the skin lesions began to fade spontaneously within several months to a few years after onset. ULC has been reported rarely, with only about 20 cases worldwide and no cases described in the Korean literature.
Assuntos
Humanos , Biópsia , Extremidade Inferior , Pele , DermatopatiasRESUMO
No abstract available.
Assuntos
Abscesso , Osteonecrose da Arcada Osseodentária Associada a DifosfonatosRESUMO
Rudimentary polydactyly is a congenital anomaly of the hand clinically ranging from a small wart-like tumor to a pedunculated structure near the thumb or little finger. The histology reveals a marked neural proliferation, dilated blood vessels, and some Meissner corpuscles in the dermis. The etiology is unknown and there are a few theories. First, Hare believed that it represented a vestigial form of supernumerary finger, and termed it rudimentary polydactyly. Since then, Shapiro et al. has argued that rudimentary polydactyly is an amputation neuroma after finding histological similarity between acquired traumatic neuroma and rudimentary polydactyly. Recently Brehmer- Andersson et al. asserted that rudimentary polydactyly is a neuroma that can arise in any area containing Meissner corpuscles after observing a penile lesion with similar histology as rudimentary polydactyly. We report a case of rudimentary polydactyly characteristically not showing any prominent Meissner corpuscles. With this case, we provide support for the theory of Shapiro et al.
Assuntos
Amputação Cirúrgica , Vasos Sanguíneos , Derme , Dedos , Mãos , Lebres , Neuroma , Polidactilia , PolegarRESUMO
No abstract available.
Assuntos
Adulto , Humanos , Acrodermatite , Pitiríase Rubra Pilar , Pitiríase , ZincoRESUMO
Trichorhinophalangeal syndrome (TRPS) is a rare autosomal dominant hereditary disease caused by mutations in the TRPS1 or the EXT1 gene. Patients show 3 different forms (TRPS I-TRPS III) of this condition sharing similar clinical features including sparse hair, a bulbous nose, an elongated philtrum, short stature, and shortened phalanges. A 10-year-old girl presented with sparse hair and thin hair shafts since birth. She also showed a bulbous nose, an elongated philtrum, brachydactyly of the great toes, and a short stature. Radiological examination showed cone-shaped epiphyses and shortened phalanges. Genetic analysis revealed a novel missense mutation c.2759G>C (p.Trp920Ser) in the TRPS1 gene. We diagnosed this patient with TRPS type III. To our knowledge, only 3 reports have described a genetically analyzed TRPS1 gene mutation among the 11 reported cases of TRPS in the Korean literature. Furthermore, we identified a novel missense mutation in the TRPS1 gene.
Assuntos
Criança , Feminino , Humanos , Braquidactilia , Epífises , Doenças Genéticas Inatas , Cabelo , Lábio , Mutação de Sentido Incorreto , Nariz , Parto , Dedos do PéRESUMO
Granuloma annulare is a benign granulomatous skin disease, clinically characterized by dermal papules tending to form annular shapes. Granuloma annulare is classified into localized, generalized, subcutaneous, and perforating types. Localized granuloma annulare is likely to resolve spontaneously, while generalized granuloma annulare usually takes a chronic course. Topical steroids, phototherapy, isotretinoin, dapsone, hydroxychloroquine, and other various treatments have been proposed, but some cases have been resistant to all of those treatment modalities. We experienced 3 cases of generalized granuloma annulare demonstrating a recalcitrant course that were successfully treated with methotrexate and propose that methotrexate may be an effective option for recalcitrant generalized granuloma annulare treatment.
Assuntos
Dapsona , Granuloma Anular , Granuloma , Hidroxicloroquina , Isotretinoína , Metotrexato , Fototerapia , Dermatopatias , EsteroidesRESUMO
No abstract available.