RESUMO
Somatotrophic deficiency (SDMT) can be due to a deficiency of growth hormone releasing hormone(GHRH), growth hormone (GH) or insulin like growth factor I (IGF-I). Although its clinical features have been thoroughly described, the diagnosis is still controversial. Now there is an effective treatment with GH or IGF-I for these patients. AIM: To analyze the main clinical, etiological and laboratory characteristics of 75 SD patients (44 males), aged 9.4 + 4.5 years, with severe growth retardation. The diagnosis was confirmed by the lack of response to two GH stimulation tests (Clonidine, Glugagon or Insulin) and low levels of IGF-I or insulin-like growth factor binding protein- 3 (IGFBP-3). RESULTS: In 34 patients (46 percent), the cause of DSMT was considered idiopathic (DSMT-I), in 31 (41 percent) there was an organic cause (DSMT-O), most commonly caused by malformations or pituitary tumors and in 10 (13 percent), it was genetic (DSMT-G) (three patients with Laron's Syndrome, five with mutations of GH gene and 2 with probable mutations of Prop-1 and Pit-1 genes). IGF-1 levels, were significantly lower in DSMT-O and DSMT-G thanin DSMT-I (21.2 +/- 46.1, 23.4 +/-30.3 ng/mL and 50.2 +/- 48.3 ng/mL, respectively). The lowest height score corresponded to DSMT-G, compared to DSMT-O and DSMT (5.7 +/- 0.9, -4.0 +/- 1.6 and 4.3 +/- 1.2 DS, respectively) CONCLUSIONS: The high percentage of organic and genetic etiologies in our patients can be due to the systematic search of these diseases. DSMT-G (Laron, mutations in GH and Pit-1 genes) had the most severe growth retardation.
Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Estatura , Hormônio do Crescimento/deficiência , Transtornos do Crescimento/diagnóstico , Transtornos do Crescimento/etiologia , Antropometria , Chile , Nanismo/etiologia , Estudos Retrospectivos , Fator de Crescimento Insulin-Like I/análise , Hormônio do Crescimento/análise , Hormônio do Crescimento/genética , Mutação , Peso Corporal , /análise , Transtornos do Crescimento/genéticaRESUMO
El reemplazo de un diente anterior en una cita, con una técnica que de resultados estéticos y funcionales, que preserve tanto como sea posible la estructura de los dientes pilares y que sea económico para el paciente, es uno de los mayores desafíos para el dentista. El uso de fibras reforzadas Ribbond, adhesivos recientes y los nuevos composites disponibles hoy en día, permiten utilizar una técnica rápida, conservadora y sobre todo estética
Assuntos
Humanos , Masculino , Adulto , Resinas Compostas/química , Colagem Dentária , Prótese Parcial Fixa/normas , Estética Dentária , Ácidos Fosfóricos/química , Cimentação/instrumentação , Condicionamento Ácido do Dente/métodos , Polietilenos/químicaRESUMO
The human uterotrophic placental factor (hUTPF) is a protein obtained from human term placentae and acts on uterine growth, mammary gland, and blastocyst development and implantation. In the present work, we further define some molecular characteristics of hUTPF using chromatographic, electrophoretic and immunochemical methods. It is concluded that in human term placenta a high molecular weight hUTPF is present, bound to albumin and immunoglobulins, which could represent a storage or transport form of this factor. hUTPF presents several molecular forms, one of them of 270 kDa and others of approximately 90 kDa and 27 kDa