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1.
Medical Forum Monthly. 2010; 21 (4): 35-37
em Inglês | IMEMR | ID: emr-97697

RESUMO

The purpose of this study was to assess the blood levels of zinc [Zn] and iron [Fe] in of children. This descriptive was carried out in the Department of Chemistry, Bahauddin Zakariya University, Multan, PMRC Research Center, Nishtar Medical College, Multan, Department of Paediatric Medicine, Nishtar Medical College, Multan, Pakistan. 2004-2005. One hundred children [boys and girls] aged 1-10 years belonging to rural and urban areas attending the out patient department for minor illnesses at Nishtar Hospital, Multan were included in this study. Information regarding age, height, weight, history of past illnesses and dietary food frequency were recorded. Flame atomic absorption spectrometry was used as an analytical tool to quantify zinc and iron concentrations. Whole mean blood Zn and Fe levels in children were found to be as 759 +/- 243 microg/100 ml and 38.8 +/- 5.5 mg/000 ml respectively. Relationship of blood Zn and Fe levels with age of the children were determined. Results indicate that blood zinc and iron levels in the children were lower than the normal reference values. This study suggests that mineral rich diet should be given to the children of this region for their healthy growth


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Ferro/sangue , Pacientes Ambulatoriais
2.
JPMA-Journal of Pakistan Medical Association. 1997; 47 (1): 24-28
em Inglês | IMEMR | ID: emr-45116

RESUMO

A knowledge, attitude and practices [K.A.P.] survey was conducted among doctors working as general practitioners [GP] in Multan, for diagnosis and management of acute respiratory infections [ARI] in children under five years of age. GPs in Multan were not familiar with national ARI control programme and rational drug use guidelines. They rarely asked about symptoms describing severity of disease while taking patient histories and did not look for signs of severe pneumonia during physical examinations. Most patients diagnosed as URTI [upper respiratory tract infection] received oral antibiotics and those with pneumonia received injectable antibiotics. Other drugs prescribed included cough syrups, antihistamines and antipyretics. The average number of drugs prescribed per patient was 3.4. The doctors were deficient in providing home care advice for sick children to the caretakers. Average time spent by doctors on each patient was two minutes and twenty-three seconds. A combination of biomedical and social factors help to perpetuate this irrational prescribing behaviour of the GPs. Continuing education programmes for doctors in general practice about ARI management in children and rational use of drugs and health education of the public may improve the current prescribing practices


Assuntos
Humanos , Doença Aguda , Padrões de Prática Médica , Médicos de Família , Medicina de Família e Comunidade , Morbidade , Proteção da Criança , Métodos Epidemiológicos
3.
JPMA-Journal of Pakistan Medical Association. 1989; 39 (2): 50-53
em Inglês | IMEMR | ID: emr-13500

RESUMO

Inftuence of alloxan induced metabolic disorder on the biodisposition kinetics of a weakly acidic drug sulphadiazine was investigated in rabbits. In 12 rabbits, mean +/- SD blood pH was 7.45 +/- 0.05, plasma glucose 123 +/- 10.6 mg%, plasma total lipids 336 +/- 124 mg% and plasma urea 36 +/- 6 mg%. After treatment with mg/kg alloxan intravenously the blood pH was 7.20 +/- 0.06, plasma glucose 393 +/- 80.3, total 532 +/- 181 and plasma urea was 48 +/- 10 mg%. Disposition kinetics showed that the plasma concentration of sulphadiazine was significantly [P<0.01] in normal condition when compared with that of metabolically altered. The zero-time plasma concentration was significantly [P< 0.01] higher, apparent volume of distribution and total body clearance were significantly [P< 0.01] lower in the normal than in the metabolically altered condition of rabbits. Elimination rate constant and the half-life did not reveal any significant difference in the normal and metabolically altered conditions. studies demonstrate that the clinical biochemical conditions can influence the disposition kinetics and fate of weakly acid, and possibly of the weakly basic drugs. Therefore, the therapeutic was standards the drugs need be verified in the condition in which the drugs are to be employed clinically


Assuntos
Diabetes Mellitus/metabolismo , Coelhos
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