RESUMO
This study explores the effect of structural changes of novel sulfonamide based-surfactants on surfactant behavior and antimicrobial activity. In order to better meet this as our primary goal, three different series, biphenyl-4,4'-disculfonamides [Series A,A[1-4]], amine acid salts of bis [2-aminophenyl] biphenyl-4,4'-disulfonamide [Series C,C[1-2]] were prepared. The structures of the desired compounds wee confirmed by using elemental analysis, Fourier translform infrared spectroscopy [FT-IR], proton nuclear magnetic resonance [[1]H NMR] and UV-Vis spectral analysis. In addition to these spectroscopic measurements, compounds C[1] and C[2] [Series C] were subsequently characterized extensively by atomic absorption methods. Also as our secondary goal, we have measured surface properties as follows: surface tension [gamma], critical micelle concentration [cmc], the surface excess concentration [T [max]] and the cross-sectional area per adsorbed surfactant head group [A[min]]. The investigation was continued to cover the antibacterial and antifungal screening for all synthesized compounds. In addition, some selected compounds were screened for cytotoxicity against human turnor cell lines - MCF7 [breast carcinoma]m HEPG2 [liver carcinoma] and HCT116 [colon carcinoma]