1.
Indian J Exp Biol
;
1997 Jul; 35(7): 765-770
Artigo
em Inglês
| IMSEAR
| ID: sea-61023
RESUMO
HL 707, Liroldine, a novel synthetic compound, was found effective against both extraintestinal and intestinal amoebiasis in animal models. Its activity against hepatic infection in golden hamsters is comparable with that of different derivatives of nitroimidazoles used for human treatment. Against intestinal amoebiasis in Wistar rats, the activity was superior to nitroimidazoles and chloroquine. Paramomycin was comparable and diloxanide furoate was marginally superior. The comparative in vitro and in vivo studies with standard marketed drugs and Liroldine indicate an excellent profile of the compound against experimental amoebiasis. LD50 of Liroldine determined in mice is 910 mg/kg x 1, po and 940 mg/kg x 1 ip).
Assuntos
Amebíase/tratamento farmacológico , Amebicidas/uso terapêutico , Animais , Compostos de Bifenilo/uso terapêutico , Cricetinae , Humanos , Enteropatias Parasitárias/tratamento farmacológico , Hepatopatias Parasitárias/tratamento farmacológico , Mesocricetus , Camundongos , Testes de Sensibilidade Microbiana , Pirrolidinas/uso terapêutico , Ratos , Ratos Wistar
2.
J Indian Med Assoc
;
1968 Apr; 50(8): 349-52
Artigo
em Inglês
| IMSEAR
| ID: sea-104482
3.
J Indian Med Assoc
;
1965 Oct; 45(7): 357-62
Artigo
em Inglês
| IMSEAR
| ID: sea-102181
4.
J Indian Med Assoc
;
1964 Mar; 42(): 203-12
Artigo
em Inglês
| IMSEAR
| ID: sea-104126
5.
J Indian Med Assoc
;
1964 Mar; 42(): 212-9
Artigo
em Inglês
| IMSEAR
| ID: sea-102999