RESUMO
Background: Prostate cancer incidence is rising leading to a major health problem globally. Infectious complications in TRUS guided prostate biopsy are very common without antibiotic prophylaxis
Objective: To compare the effect of single dose and three day ciprofloxacin prophylaxis regimen for prevention of urinary tract infection after prostatic biopsy
Methodology: This randomized controlled trial involved 130 patients with Prostate cancer which were randomly allocated into 2 groups. Group-A received two ciprofloxacin 500 mg tablets stat while Group-B received 3 days has of ciprofloxacin treatment. Patients were followed up to 5 days to observe any symptoms of UTI. Written informed consent was taken from all the patients. The data was entered and analyzed using SPSS version 19
Results: The mean age of the patients was 56.84 +/- 7.28 years. The mean age of the patients in Group-A was 56.44 +/- 7.10 years while in Group-B it was 57.23 +/- 7.50 years. However, there was no statistically significant difference between groups in terms of age. On follow up at 5 days, 11 patients has UTI. The rate of presence of UTI was similar across different age groups and treatment regimens. Treatment with one-day antibiotic prophylaxis resulted in UTI in 6[9,2%] associated with in comparison to three days' antibiotic treatment, where 5 [7.6%] has UTI. [P=0.64]
Conclusion: The incidence of UTI with one-day antibiotic prophylaxis with ciprofloxacin was comparable to three antibiotic treatments in patients who are candidates for TRUS guided biopsy