Tumor markers in breast carcinoma: prognostic significance

In an attempt to identify biologic markers that might predict prognosis in patients with breast cancer, the serum levels of three tumor- associated antigens: CA 15.3, CEA, and 5-N were determined in 51 patients with infiltrating breast carcinoma, 70 patients with benign breast disease, and 50 normal females as controls. The mean values of these markers in breast cancer were significantly higher than those of bengin breast tumor and control groups There was significant correlation between each of CA 153, CEA, and 5-N with rumor size. Also a significant correlation existed between each of CA 153, and CEA with number of lymph nodes involved, while no significant correlation existed between -5-N, and lymph node involvement [r 0.19]. It is suggested that simultaneous determination of CA 15.3, CEA, and -5-N seem to be of value as sensitive indicators for earlier detection of metastases or recurrences and potentially useful for evaluation and monitoring of patients with breast cancer

Fine needle aspiration biopsy of thyroid lesion: a comparative study between cytological and histopathological findings

Fine needle aspiration biopsy [FNAB] was performed on 189 patients with thyroid lesions. 75 cases were studied cytologically and histopathologically, 2 cases were diagnosed as suspicious cytologically, proved to be malignant by histopathology, 66 cases were diagnosed benign cytologically, by histopathological examination 65 were benign and one case was malignant [false negative]. Thyroid FNAB is recommended as a preoperative procedure in the diagnosis of thyroid lesions

Fine needle aspiration of breast tumours: a review of 202 cases

Two hundred and two breast aspirate specimens were examined cytologically. Ninety six cases were diagnosed as benign lesions agreeing with histopathological results. Seventeen cases were diagnosed cytologically as atypical suspicious for malignancy; histopathological studies showed that eight out of this group to be malignant, while the remaining nine cases showed benign changes. Thirty five specimens were diagnosed cytologically as positive for malignancy, the same results were seen histopathologically. On the other hand the remaining fifty four cases were insufficient for cytodiagnosis