A Case of Androgenetic Alopecia Associated with Cushing's Disease / 대한피부과학회지

Cushing's disease is an ACTH-producing pituitary corticotrope adenoma. This pituitary adenoma exhibits an unrestrained ACTH secretion resulting in hypercortisolemia. A 27-year-old female visited us with a 3-year history of diffuse hair loss on the scalp. Her past medical history included recently-developed hypertension and 10 years of increased weight gain and oligomenorrhea. Central obesity, hirsutism, acne, violet striae on the abdomen, lower and upper extremities, and christmas tree-shaped alopecia on the scalp were observed upon physical examination. The secretion of cortisol was not suppressed in both a low and high dose dexamethasone suppression test. A brain MRI detected a pituitary microadenoma in the sella turcica. Based on the clinical and laboratory findings, we diagnosed androgenetic alopecia associated with Cushing's disease. After surgical removal of the pituitary adenoma, the alopecia showed a remarkable improvement. We report a case of Cushing's disease found in a patient with androgenetic alopecia.

A Case of Paronychia Occurring after Injection with Cetuximab (Erbitux(R), IMC-C225) / 대한피부과학회지

We report a case of paronychia induced by cetuximab in a 43-year-old woman. Cetuximab is an antibody to the epidermal growth factor receptor, and has previously been shown to block the proliferation of various cancer cells. The patient had taken cetuximab for the treatment of metastatic rectal cancer. One month after the injection of cetuximab, the patient visited our clinic with painful periungal edema and erythema. The lesions partially improved after treatment with systemic and topical antibiotics. But, after discontinuing cetuximab, there was a significant decrease in the erythematous and edematous plaques. Three weeks later, she was asymptomatic and the lesions had resolved completely.

A Case of Microvenular Hemangioma Clinically Mimicking Kaposi's Sarcoma / 대한피부과학회지

Microvenular hemangioma is an uncommon aquired vascular tumor, occurring in young to middle-aged adults of both genders. It usually presents as a small, solitary, purple-to-red papule, nodule or plaque on the extremities or trunk. Histologically, the tumor is composed of small branching venules with collapsed lumina and conspicuous pericytes infiltrating the full thickeness of the reticular dermis. Herein, we report a case of microvenular hemangioma, clinically mimicking Kaposi's sarcoma, on the toe of the right foot in a 44-year old male.

A Case of Kaposi's Sarcoma Associated with Castleman's Disease / 대한피부과학회지

Castleman's disease, also known as angiofollicular lymphoid hyperplasia or giant lymph-node hyperplasia, is an unusual form of a lymphoproliferative disorder, and is divided clinically into a solitary and a multicentric form. The multicentric form of Castleman's disease is almost always of the plasma cell type. This can coexist with Kaposi's sarcoma in some cases. Kaposi's sarcoma is a multicentric, proliferative, vascular tumor involving cutaneous and visceral tissue. Iatrogenically-developed, immunosuppression-associated Kaposi's sarcoma is usually the result of immunosuppressive therapy. A 61-year-old man diagnosed as the plasma cell type of Castleman's disease, who had been treated with prednisolone for 2 years, was referred to the department of dermatology with numerous skin lesions consisting of confluent, violaceous-colored papules and plaques on his palm and soles. Histologic examination of the cutaneous lesions showed consistency with Kaposi's sarcoma. We report a rare case of Kaposi's sarcoma associated with multicentric Castleman's disease.

A Case of Contact Dermatitis from Henna Tattooing / 대한피부과학회지

The art of body adornment by body piercing and tattooing has become increasingly popular in our modern culture. Temporary henna tattoos are readily available worldwide, last several weeks on the skin, and offer a self-limited, convenient alternative to a permanent tattoo. The addition of para-phenylenediamine (PPD), which is widely recognized as a sensitizer, increases the risk of allergic contact dermatitis from these henna tattoo mixtures, and a number of cases have been reported. We report a case of contact dermatitis from a henna tattoo mixture, which was diagnosed by the patch test and identification and quantification of PPD and nickel in a temporary henna tattoo.

A Case of Facial and Axillary Lupus Miliaris Disseminatus Faciei / 대한피부과학회지

Lupus miliaris disseminatus faciei (LMDF) is a papulo-pustular eruption typically affecting the face of young adults. It is characterized histologically by the presence of caseating granuloma in the dermis. The lesions are typically described to affect the periorbital and muzzle skin of the face, however, only three cases with axillary involvement have been described in the literature. We report a case of LMDF on the face and left axilla of a 44-year-old female. She presented with a 7-month history of a mildly-pruritic papulopustular eruption on the face. The histologic examination showed the homogenous necrosis surrounded by granulomatous inflammation containing epithelioid macrophages, lymphocytes, and multinucleated giant cells in the dermis. Two months later, a solitary palpable nodule developed on the left axilla and its histological features showed similarity with the eruption on the face. A diagnosis of LMDF was made based on the clinical and histological findings. We hereby report an interesting and rare case of LMDF with axillary involvement.

A Case of Pyoderma Gangrenosum Associated with Autoimmune Chronic Active Hepatitis / 대한피부과학회지

Pyoderma gangrenosum (PG) is an inflammatory ulcerative condition of unclear etiology. In more than 50% of cases, lesions occur in association with an underlying systemic disorder-most notably; inflammatory bowel disease (IBD), rheumatoid arthritis, or a hematologic abnormality. Here, we report a rare case of pyoderma gangrenosum associated with autoimmune chronic active hepatitis. A 34-year-old woman presented with a 2-month history of a painful ulceration on her back. She was clinically diagnosed as having pyoderma gangrenosum and an appropriate exclusion was performed. She had abnormal results for liver biochemical tests, with a hepatitis-like picture and high titer of antinuclear antibodies. According to the scoring system proposed by the International Autoimmune Hepatitis Group she had `definite' autoimmune hepatitis and responded well to immunesuppressive treatment.