RESUMO
Objective: present study was designed to find out the frequency of hepatic hydrothorax among the patients with liver cirrhosis in a tertiary care hospital
Methods: this prospective observational study was carried out at the Hepatology Section of Department of Medicine, Isra University Hospital, Hyderabad, from December 2005 to May 2006. All the consecutive patients suffering from cirrhosis of liver were included and studied for the presence of hepatic hydrothorax. Results were summed up and test parameters were compared statistically
Results: the total number of patients was 128, and the mean age of these patients was 48.6 years. Frequency of hepatic hydrothorax in all patients with cirrhosis was 5.5% [7/128]. It was seen that highest frequency of hepatic hydrothorax was found in Hepatitis C cirrhotic patients [4/7]. The second most common occurrence was found in hepatitis B cirrhotic patients [2/7]. In other types [non "B", non "C"] it was 1/7
Conclusion: the frequency of hepatic hydrothorax at our center is similar as reported in the world literature
RESUMO
Objective: to determine the coagulation abnormalities in patients with lung cancer
Study design: case-control study
Place and duration: department of Pathology Isra University Hospital Hyderabad, Sindh - Pakistan, and Department of Medicine Liaquat University of Medical and Health Sciences Jamshoro, Sindh - Pakistan, from June 2006 to December 2007
Patients and methods: seventy subjects were recruited for the study by non-probability convenient sampling technique. Forty freshly diagnosed histopathology proven lung cancer patients were taken as cases, whereas 30 healthy subjects comprised the control group. Platelet count [PLT] was done on hematology analyzer while prothrombin time [PT], activated partial thromboplastin time [APTT] and plasma D-dimer tests were performed by commercially available kits at Department of Pathology, Isra University Hospital Hyderabad, and Sindh - Pakistan. T test was applied to determine the significance of differences between two groups whereas P value up to .05 was taken as significant
Results: the mean +/- SD PLT in cases and controls was 394 +/- 170 and 216 +/- 73 respectively. The mean +/- SD values for these respective groups were for PT 14.7 +/- 0.5 and 12.6 +/- 0.4, for APTT 41.5 +/- 6.2 and 25.8 +/- 3.7. D-dimer levels were <500 in all 30 controls whereas these were up to 2000 in cases
Conclusion: there is a strong relationship between coagulation abnormalities and lung cancer. D-dimer is very sensitive for evaluation of fibrinolysis related with lung cancer