RESUMO
Introduction: Myeloid malignancies are clonal disorders of hematopoietic stem/precursor cells. The criteria for the diagnosis of acute myeloid leukemia [AML] are based on morphological cytogenetic and flow-cytometric findings. The prognostic outcome with intensive chemotherapy is better than with non-intensive treatment
Purpose/Objectives: To determine the frequency of various clinical and pathological findings in myeloid malignancies
Study Design: Cross sectional descriptive study
Place and Duration of Study: The study was carried out at Department of Pathology from October 2014 to December 2016
Material/Patients and methods: Detailed history, clinical and pathological findings recorded on a pre-designed proforma including bone marrow reports was evaluated
Results: During period of study, 351 proformas including bone marrow reports were evaluated, from which 49 [30 males and 19 females; age ranges between 03 months to 60 years] were diagnosed as myeloid malignancies. The distribution of myeloid malignancies were acute myeloid leukemia [n=21], chronic myeloid leukemia [n=14], acute myelodysplastic syndrome [n=3], myeloproliferative neoplasms [n=3], myelofibrosis [n=2], myeloid hyperplasia [n=2], acute promyelocytic leukemia [n=2], myelomonocytic leukemia [n=1], ,and transient abnormal myelopoiesis [n=1].The main presenting complaints were fever and weight loss, whereas splenomegaly was the most common finding on clinical examination. The commonest laboratory finding was anemia followed by leukocytosis; while 10 patients showed pancytopenia
Conclusion: AML with fever and bicytopenia is the commonest myeloid malignancy in our series