Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia

BACKGROUND: This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment. METHODS: The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016. RESULTS: After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported. CONCLUSION: These results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy.

The Effect of Temperament on Juvenile Delinquent Behavior / 신경정신의학

OBJECTIVES: The purpose of this study is to investigate the characteristics of the temperament and character of juvenile delinquents, and to explore the effect of those factors on juvenile delinquent behavior. METHODS: 128 male and 29 female juvenile delinquents on probation, and 66 male and 69 female students in the 10th and the 11th grade, completed Junior Temperament and Character Inventory (JTCI), anxiety, depression scales and Latent Delinquency Questionnaire. RESULTS: Male juvenile delinquents showed significantly higher 'novelty seeking', and lower 'harm avoidance' and 'persistence' in JTCI subscales, compared to normal control group. Stepwise multiple-regression analysis showed that 'novelty seeking' and 'harm avoidance' were significantly predicting juvenile delinquent behavior. In the case of the female adolescents, delinquent group was significantly lower 'harm avoidance' than normal groups, and stepwise multiple regression analysis showed 'self-transcendence' was the only significant predicting variable for juvenile delinquent behavior. CONCLUSION: Based on the results, temperament was related to the juvenile delinquent behavior especially for male delinquent adolescents.