Effects of Dexamethasone on Endothelin-1(ET-1) Production by Keratinocytes

Epidermal keratinocytes are important sources of a wide variety of cytokines that include the endothelin-1 (ET-1). Glucocorticoids have been shown to inhibit the production of several cytokines. However, their effect on ET-1 synthesis by keratinocytes is still unknown. It has been reported that ultraviolet B (UVB) irradiation stimulates both the synthesis and release of ET-1 and it was observed that ET-1 secretion by HaCat cells increased with increasing UVB exposure. In this study, the effects of glucocorticoid on ET-1 production were evaluated using cultured HaCat keratinocytes. The results showed that dexamethasone suppressed basal re-lease of ET-1. In addition, it strongly inhibited the UVB-mediated augmentation of ET-1 production. Furthermore, lincomycin slightly enhanced the inhibitory effect of dexamethasone on ET-1 synthesis.

Generalized Perforating Granuloma Annulare / 대한피부과학회지

Generalized perforating granuloma annulare is a rare atypical type of granuloma annulare. It has typical clinicopathological features. We report a case of generalized perforating granuloma annulare in a 31-year-old woman. In our case, erythematous scaly and umbilicated papules were on the whole body, and histopathological finding showed that the transepidermal elimination and the deposition of degenerated collagen in the dermis with palisading granuloma.