Doxazosin as a treatment of erectile dysfunction: Double blind placebo controlled study

To evaluate the therapeutic value of doxazosin mesylate salt tables in the treatment of erectile dysfunction, a double blind placebo controlled study was done on 60 married male patients suffering from erectile dysfunction [ED]. Patients received daily either doxazosin or placebo for 6 weeks. Change in sexual function was assessed by using international Index of erectile function [IIEF,]. Significant statistical improvements were detected regarding erectile function [23.3% of patients] orgasmic function [13.3% of patients], and all over satisfaction [26.6%]. Effect of doxazosin on these three sexual domains appeared to be not dependant on its effect on relieving lower urinary symptoms [LUTS], as it significantly improves erectile function, orgasmic function and over all satisfaction in both drug [LUTS] and non [LUTS] subgroups compared by placebo [LUTS] and non [LUTS] subgroups

Evaluation of multiple transrectal ultrasound guided biopsies of the prostate for the detection of prostate cancer

To evaluate different regimens used in transrectal [TRUS] guided biopsy and to identify the optimal [TRUS] biopsy regimen, a prospective study included 80 consequent men undergoing biopsy either because of an elevated PSA> 4 ng/ml and/or abnormal digital rectal examination. Biopsies yielded 34 patients with prostate cancer giving a positive biopsy rate of 42.5%. Traditional sextant biopsy diagnosed 30 patients [88.2%]out of 34 patients with prostate cancer, while laterally directed biopsies detected 32patients [94%]. Positive transitional biopsy was positive in only two patients. No single case of prostate cancer was diagnosed only by transitional zone biopsies. The highest detection rate among traditional sextant biopsy sites were at the apex [88%] while the lowest were at the base [67.4%]. None of patients developed major complications. A sextant biopsy, far laterally oriented, regimen is the optimum transrectal biopsy regimen for detection of prostate cancer

Doxazosin as a treatment of erectile dysfunction: double blind placebo controlled study

To evaluate the therapeutic value of doxazosin mesylate salt tablets in the treatment of erectile dysfunction, a double blind placebo controlled study was done on 60 married male patients suffering from erectile dysfunction [ED]. Patients received daily either doxazosin or placebo for 6 weeks. Changes in sexual function was assessed by using international Index of erectile function [IIEF]. Significant statistical improvements were detected regarding erectile function [23.3% of patients] orgasmic function [13.3% of patients], and all over satisfaction [26.6%]. Effect of doxazosin on these three sexual domains appeared to be not dependant on it's effect on relieving lower urinary symptoms [LUTS], as it significantly improves erectile function, orgasmic function and over all satisfaction in both drug [LUTS] and non [LUTS] subgroups compared by placebo [LUTS] and non [LUTS] subgroups