Neutropenia related to captopril

Two patients are described with severe neutropenia which developed during captopril therapy. The first patient received captopril for congestive cardiac failure. She developed neutropenia within 5 weeks of captopril therapy, complicated by infection which proved to be fatal. The second patient was suffering from systemic lupus erythematosus [SLE], hypertension and renal failure. While on captopril therapy she developed severe neutropenia which reverted to normal after discontinuing the drug