RESUMO
La esclerosis múltiple (EM) es una enfermedad crónica del sistema nervioso central (SNC) que desarrolla cuadros clínicos muy variados, puede progresar con brotes, dejar secuelas entre ellos, y tener un lento curso discapacitante. Sin embargo, en algunas personas los brotes tienen compromiso múltiple del SNC, rápido deterioro de la discapacidad, y otros factores de riesgo de mal pronóstico de la enfermedad. Aunque no hay consenso sobre su definición, estas características indican que estamos ante una EM de alta actividad. Poder identificar la EM de alta actividad de forma precoz nos permite individualizar su tratamiento y usar drogas de alta eficacia. Nosotros describimos la dificultad para conciliar una definición apropiada de M de alta actividad y la necesidad de usar de forma precoz drogas de alta eficacia en aquellas EM de alta actividad que se presentan desde el inicio de la enfermedad
Multiple sclerosis (MS) is a chronic central nervous system (CNS) disease that may have variable clinical manifestations, it may progress as flares, leaving sequels between such flares, and have a slow disabling course. However, in some persons, MS flares lead to marked CNS involvement, rapid disability progression, and to other factors that lead to a poor prognosis for this disease. Although there is no consensus for a definition, these features may indicate that the condition is a highly active form of MS. Being able to early identify highly active MS would allow us to have individualized therapy and use highly efficacious drugs. In this paper we describe how difficult it is to have an adequate definition of highly active MD, and the need for early start using highly efficacious drugs for these highly active forms of MS that occur as early flares of the disease