De la atención de un brote por un patógeno desconocido en Wuhan hasta la preparación y respuesta ante la emergencia de Covid-19 en México / From the handling of an outbreak by an unknown pathogen in Wuhan to the preparedness and response in the face of the emergence of Covid-19 in Mexico

Resumen El 31 de diciembre de 2019, las autoridades chinas de salud informaron a la comunidad internacional, a través de los mecanismos establecidos por la Organización Mundial de la Salud (OMS), de una epidemia de neumonía con etiología desconocida en Wuhan, provincia de Hubei. Los primeros casos se notificaron a inicios de ese mes y se vincularon al antecedente de visitar un mercado de comida y animales vivos. El 7 de enero de 2020 se logró el aislamiento y reconocimiento del patógeno responsable mediante secuenciación de siguiente generación, mientras el número de afectados continuaba en ascenso. La publicación de genomas completos del nuevo coronavirus identificado (inicialmente denominado 2019-nCoV, ahora designado SARS-CoV2) en bases de datos públicas y privadas, de protocolos diagnósticos estandarizados y de la información clínica epidemiológica generada permitirá atender la Emergencia de Salud Pública de Importancia Internacional (ESPII) declarada el 30 de enero por la OMS. Con este documento pretendemos aportar a la caracterización de la epidemia de neumonía, ahora llamada enfermedad por coronavirus (Covid-19), revisar las fortalezas que tiene México en el concierto de la salud global e invitar a los profesionales de la salud a incorporarse a las actividades de preparación y respuesta ante esta emergencia.

Abstract On December 31, 2019, the Chinese health authorities informed the international community, through the mechanisms established by the World Health Organization (WHO), of a pneumonia epidemic of unknown etiology in Wuhan, Hubei Province. The first cases were reported early in that month and were linked to a history of having visited a market where food and live animals are sold. On January 7, 2020, isolation and identification of the culprit pathogen was achieved using next-generation sequencing, while the number of affected subjects continued to rise. The publication of full-genomes of the newly identified coronavirus (initially called 2019-nCoV, now designated SARS-CoV2) in public and private databases, of standardized diagnostic protocols and of the clinical-epidemiological information generated will allow addressing the Public Health Emergency of International Concern (PHEIC), declared on January 30 by the WHO. With this document, we intend to contribute to the characterization of the pneumonia epidemic, now called Corona virus disease (Covid-19) review the strengths Mexico has in the global health concert and invite health professionals to join the preparedness and response activities in the face of this emergency.

Age and gender based prevalence of obesity in residents of Punjab, India

Background: Obesity is recognized as a chronic disease, associated with a variety of metabolic, cardiovascular and neurological complications. Prevalence of obesity is increasing worldwide, more so in the developing countries. It is affecting both sexes and all age groups. Body mass index BMI along with presence and severity of obesity associated complications are used to identify, successively increasing stages of obesity. The present study aims to study prevalence of overweight, obesity (stage 0,1,2) and morbid obesity in adult residents of Punjab state in an effort to determine burden of this lifestyle disorder in different age groups and sexes, so that a comprehensive action plan can be designed to target appropriate group with specific preventive measures .Methods: 1000 subjects were surveyed and labelled as non-obese, overweight, obese or morbid obese based on their BMI, presence and severity of obesity related complications. Point prevalence amongst different age groups of both sexes were determined and compared.Results: In study population 41.5% subjects were non-obese, 15.9% were overweight, 29.4% were obese and 13.2% were morbidly obese. The prevalence of all the 3 conditions (overweight, obesity and morbid obesity) increased with increasing age in both sexes. The prevalence was more among females of all age groups than males for ‘overweight’ and ‘obesity’. But gender based difference narrowed down with increasing severity of disease, such that female to male ratio reversed (<1) for morbid obesity. Moreover, peak prevalence of overweight and obesity were attained little later in females as compared to males. However, for morbid obesity peak prevalence is seen in same age group (40-49 years) in both sexes.Conclusions: Overweight and obesity are more prevalent among females of all age groups than males with peak prevalence achieved little later in females as compared to males. However, gender based differences in prevalence decreased as severity increased and morbid obesity was more prevalent among males than females.

Comparative evaluation of the surface tension and the pH of calcium hydroxide mixed with five different vehicles: an in vitro study.

AIM: The aim of this study was to evaluate the surface tension and pH of five different vehicles that are used as potential agents to mix calcium hydroxide in root canal treatments and to compare them with the final surface tension and pH of calcium hydroxide mixed with these vehicles. MATERIALS AND METHODS: The study was carried out in two phases. In Phase I, the surface tension and pH of five vehicles (distilled water, saline, anesthetic solution, chlorhexidine, and glycerin) were evaluated using a Du Nuoy Tensiometer and a pH Meter. In Phase II, a predetermined amount of calcium hydroxide was mixed with the individual vehicles and the surface tension and pH was determined. In each group, seven samples were evaluated. RESULTS: Among the individual vehicles, chlorhexidine had the least surface tension values (39.8+1.1 dynes/cm). Among the various calcium hydroxide mixtures, calcium hydroxide with chlorhexidine showed the least surface tension values (36.4+1.1 dynes/cm). All the vehicles showed an acidic pH ranging from 5 to 6.5. There was a significant increase in the pH values with the addition of calcium hydroxide to the respective vehicles. The calcium hydroxide mixtures had an alkaline pH ranging from 9 to 11.5; the highest pH was observed for calcium hydroxide mixed with distilled water and saline (11.5+0.2). CONCLUSION: The surface tension and pH of the vehicles directly influenced the surface tension and pH of the calcium hydroxide mixtures. Chlorhexidine was found to be a better vehicle for calcium hydroxide when used as an intracanal medicament.

Anatomical variations of mandibular premolars in Chennai population.

AIM: To analyse the prevalence of anatomical variations of mandibular premolars in Chennai population. METHODOLOGY: It was observed, during the routine treatment of mandibular premolars that aberrations were becoming common. This necessitated an encompassing study on 500 patients, evaluating the occurrence of these aberrations. The parameters of this study included sex predilection, unilateral/ bilateral occurrences, and comparison of the incidence of anatomical variations in mandibular first and second premolar canal configuration. The study pattern was designed to observe these premolars using Radiovisiography (RVG) in different angulations to highlight the anatomical aberrations. The results were subjected to statistical analysis, which were performed using SPSS (Statistical Package for Social Science) statistical program version 10.0.5. Descriptive statistics were computed for all the variables. RESULT: The present study revealed high incidence of anatomical aberrations in mandibular premolars among Chennai population. Out of the 500 patients studied, 123 patients [24.6%] showed anatomical variance in the canal configuration. There was high incidence of Vertucci's Type IV canal configuration as compared to Type V, Type II and Type VIII in the descending order of occurrence. CONCLUSION: Within the limitations of this in-vivo study, it was inferred that the incidence of aberrations in the canal configuration of mandibular premolars is common and due considerations are to be given during endodontic intervention.

Hypokalemic paralysis in pregnancy.

Hypokalemic paralysis is an uncommon entity with varied etiology. Renal tubular acidosis is an unusual cause of this disorder. Its occurrence with pregnancy is rare. We report such a case and mention the implications of the association and review relevant literature breifly.