Factors Influencing Medication Adherence in Patients with Hypertension: Based on the 2008 Korean National Health and Nutrition Examination Survey

PURPOSE: The purpose of this study is to examine factors influencing medication adherence in patients with hypertension. METHODS: This study carried out a secondary analysis of data from the 2008 Korean National Health and Nutrition Examination Survey (KNHANES). Stratified sampling was used to select a participant sample that was representative of patients with hypertension throughout the country. Using the SPSS/WIN 18.0 program, data were analyzed using descriptive statistics, chi2 test, t-test, and logistic regression. RESULTS: Of the patients with hypertension, 8.8% had showed non-adherence to medication. Medication adherence was associated with age, spouse, Medicare insurance, number of other diseases, and current smoking status. The cases with older age, a spouse, Medicare insurance, higher number of other diseases, and no current smoking status showed significantly high medication adherence. CONCLUSION: Nursing interventions and further studies are needed to achieve high levels of medication adherence based on factors influencing medication adherence such as age, spouse, Medicare insurance, number of other disease, and current smoking status.

Regulation of DREAM Expression by Group I mGluR

DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.

Development of Database System for Community Based Home Care in Health Center / 대한의료정보학회지

The purpose of this study was to develop a database system for visiting nurses working in a community health center. The final goal of the system is for it to be used as a nationwide database-collecting tool over the Internet for community health services. Three unique systems were developed and trialed. The first system focused on the data warehousing technology as a research centered system for a theory based database construction. The second system was a local system, which has already been utilized in a proactive health center, and had the system interface revised according to the newly developed standardized framework of the service. The third system was part of the integrated community health information system, which had the goal of general dissemination. It is clear that these systems reflect the unique characteristics and goals of the test sites, and should be supported for the Systems Life Cycle to survive. The authors plan to move to the next stage of developing an integrated nationwide health information system for community health services.

Development of Database System for Community Based Home Care in Health Center / 대한의료정보학회지

The purpose of this study was to develop a database system for visiting nurses working in a community health center. The final goal of the system is for it to be used as a nationwide database-collecting tool over the Internet for community health services. Three unique systems were developed and trialed. The first system focused on the data warehousing technology as a research centered system for a theory based database construction. The second system was a local system, which has already been utilized in a proactive health center, and had the system interface revised according to the newly developed standardized framework of the service. The third system was part of the integrated community health information system, which had the goal of general dissemination. It is clear that these systems reflect the unique characteristics and goals of the test sites, and should be supported for the Systems Life Cycle to survive. The authors plan to move to the next stage of developing an integrated nationwide health information system for community health services.