RESUMO
ABSTRACT Environmental quality is a major factor in global health that mainly affects the poorest populations. Vector- borne diseases, climate change, pollution and unintentional poisonings are recognized as the primary causes of environmental diseases burden in developing countries. The development and implementation of new technologies to reduce the impact of these risk factors on health in developing countries is a priority in the current research. In this regard, synthetic biology, a nearly new research area, has initiated a big revolution through the de novo design or rewiring of biological components, organisms, and functions with the aim to reduce the adverse effects of environmental risk factors on human health. Despite synthetic biology is well recognized for being a multidisciplinary area where biotechnologist, biologist, physicists, mathematicians and engineers play together, its integration with public health and other social sciences seems to be of relevance to apply these technologies into a practical context. In this review, we discuss the major advances in synthetic biology with potential to improve environmental quality and human health in developing countries.
RESUMEN La calidad ambiental es reconocida como uno de los factores con mayor impacto sobre la salud humana principalmente en los países en vías de desarrollo. Las enfermedades transmitidas por vectores, el cambio climático, la contaminación y las intoxicaciones no intencionales han sido reportados como las principales causas de enfermedades ambientales en estos países. El desarrollo y la implementación de nuevas tecnologías encaminadas a reducir el impacto de estos factores ambientales en la salud es una prioridad de la investigación actual. En ese sentido, la biología sintética ha iniciado una gran revolución al permitir el diseño de novo y el mejoramiento de diversos componentes biológicos, organismos y funciones biológicas que tienen el potencial de reducir los efectos adversos de estos factores en la salud humana de una manera más eficiente y económica. A pesar de que la biología sintética es reconocida como un área multidisciplinaria donde biotecnólogos, biólogos, físicos, matemáticos e ingenieros unen sus esfuerzos, su integración con el área de la salud pública y las ciencias sociales es muy importante para llevar estas tecnologías a la práctica. En esta revisión, nosotros discutimos los más importantes avances en biología sintética y su potencial para mejorar la calidad ambiental y la salud humana en países en vías de desarrollo.
Assuntos
Humanos , Saúde Pública , Doença Ambiental , Países em Desenvolvimento , Biologia SintéticaRESUMO
Depot-holders are women from the community who promote good health practice and use of clinics. They keep a stock of contraceptives and oral rehydration salts to supply other women and are paid some incentives. In 2003, the NGO Service Delivery Program (NSDP) introduced depot-holders in three types of urban area in Bangladesh as a pilot. This evaluation study was carried out to: (a) establish a baseline for measuring the impact of activities of depot-holders on a comprehensive range of indicators in the long-term, (b) make a preliminary assessment of the impact on the use of selected services of the essen-tial services package (ESP) and other indicators at the end of the pilot phase, and (c) assess the cost of introducing depot-holders and running their activities for a year. Data from the baseline and end of pilot household surveys, together with service statistics from the intervention and comparison areas, were used for assessing the changes in clinic use and commodity distribution. The study found evidence that the depot-holders transferred knowledge to women in the community, provided services, and referred women to clinics run by non-governmental organizations (NGOs). There was a large increase in the number of client contacts at the NGO clinics and in the quantity of oral contraceptive pills and oral re-hydration salts distributed by the NGOs, mostly attributable to the activities of the depot-holders. The estimated cost per depot-holder per year was Tk 15,241 (U.S. dollars 262). Overall, the performance of the depot-holders in the pilot phase suggests that they can be introduced in different types of urban area and can be effective in their dual role as providers and promoters of services.