RESUMO
To evaluate the effect of host; tumour and treatment-related parameters that might influence the local control; of early squamous cell carcinoma of the glottis treated with radiotherapy. Seventy patients with T1-T2 NOMO squamous cell carcinoma of the glottic larynx were retrospectively analyzed with a minimum 2-years follow-up. All patients were treated daily with telecobalt unit at 2 GY per fraction to doses of 60-70 GY [median 64]. The following factors were analyzed through uni and multivariate analysis; age: sex; smoking: histologic type and grade; T-extent; anterior commissure invovement: field size: total dose given: overall treatment time and salvagve therapy. The initial treatment response [CR] were 97.8% and 76% while the 5-year local control rates were 82.2% and 56% for T1 and T2 lesions, respectively. On univariate analysis, the recieved total dose was a significant factor for both initial response and local control. Initial response and local control for T1 lesions were 100% and 90%, if total dose given > 60 GY. The corresponding values for T2 lesions were 79% and 63% [P< 0.0001;< 0.001 for T1 and > 0.05 for T2]. Better response and control rates were seen among T1 and T2 patients completed their therapy within