RESUMO
Objective: To demonstrate the sonographic features of gut masses detected either incidentally or purposely through the gastrointestinal tract sonography with histological correlation to compare the detected abnormalities for their benign and malignant nature
Material and Methods: The study was conducted between September 2009 and February 2013. Ultrasound scanning was performed on 72 patients [20-75 years, mean age 46 years] presenting with clinical suspicion of underlying primary gastrointestinal pathology due to abdominal symptoms. The histological confirmation was done either through surgically resected specimen, trucut biopsy, flexible endoscopic biopsy or fine needle aspiration
Results: Out of 72 patients, upper GI tract masses included 2 distal esophageal and 7gastric cancers. Mid gut included 9 cases of primary small bowel lymphoma. Intussusception was found in 6 patients. Ileoceacal masses were found in 13 patients with one case of jejunal mass. 18 patients were diagnosed as acute appendicitis, 3 patients demonstrated appendicular mass. Large intestine revealed a single case of diverticulitis besides 15 cases of colorectal cancer. The masses were either lobulated or revealed a segmental wall thickening simulating appearance of kidney [Pseudokidney sign], or diffused wall thickening [Target sign]
Conclusion: In our experience, ultrasonography of the gastrointestinal tract is an extremely useful modality for evaluating gut masses from distal esophagus up to rectum. Sonographic appearance ofgut related masses helps to evaluate the clinical differential diagnosis. However, additional work-up may be needed in the form of contrast study, cross-sectional imaging or endoscopy for specifying the diagnosis with histological confirmation
RESUMO
The objective of this study is to develop sensitive and cost effective reverse phase high performance liquid chromatographic method for the estimation of Metoclopramide Hydrochloride in oral solid dosage formulations. A reverse chromatographic method was used with the mobile phase of Acetonitrile, 20 m M Potassium dihydrogen phosphate buffer solution [pH 3 adjusted with orthophosphoric acid] in the ratio of 40:60. The column used was Waters C18 3.9×300 mm microBondapak [RP]. The flow rate of the mobile phase was 2 ml/minute. The detector was set at the wavelength of 275 nm. This method showed good sensitivity. The linearity was also found to be excellent [gamma[2]=0.997] in the range of 5-75 microg/ml. No interfering peaks were observed at the retention time of Metoclopramide Hydrochloride when both placebo and blank samples were injected [Retention time =1.93 min]. The parameters such as specificity, linearity, range, accuracy, precision, system suitability, solution stability, detection and quantification limits were evaluated to validate this method. This method can effectively be used for quantitative analysis of Metoclopramide Hydrochloride tablet formulations because of its specificity, accuracy and convenience of use