RESUMO
Objective: to compare the diagnostic value of antibodies against mutated citrullinated vimentin [anti-MCV] and antibodies to cyclic citrullinated peptides [anti-CCP] in patients with rheumatoid arthritis
Material and Methods: a total of 88 subjects were included in the study, comprising of 58 known patients of rheumatoid arthritis [fulfilling the American College of Rheumatology Criteria].Thirty age and sex matched normal healthy volunteers were included as controls in the study. Sera of all study subjects were tested by Elisa for presence of anti-MCV and anti-CCP antibodies
Results: the sensitivity and specificity of serum anti CCP antibodies for RA was calculated to be 58.6% and 86. 7% respectively. The sensitivity and specificity of serum anti MCV antibodies for RA was calculated to be 34.5% and 70.6% respectively at the manufacturer's cutoff value of 25U/L
Conclusion: anti-cyclic citrullinated peptide antibodies have higher sensitivity and specificity for the diagnosis of RA as compared to anti-mutated citrullinated vimentin antibodies