[Sjogren's syndrome and lympho-proliferating syndrome-taking stock]

Sjogren's syndrome, the most frequent autoimmune connective tissue disorder, is associated with a risk of B lymphoid proliferation. The clinical risk factors are parotidomegaly, enlarged lymph nodes and splenomegaly. Fever, weight loss and a decline in the general health status as well as a rise in beta 2 micro globulin or the appearance of monoclonal immuno globulin in the plasma are the signs of malignant lymphoma complicating sjogren's syndrome. We discuss the therapeutic and physiopathologic implications of this ominous complication