1470 cases of sarcoma referring to Imam Khomeini hospital during an 11-year period

Sarcoma is a malignant neoplasm arising in mesenchymal tissue. It comprises 1% of adult malignancies and 15% of childhood neoplasms. The present study was designed to review the clinical characteristics of 1470 sarcoma cases and related predictors of out come, relapse and survival. For this retrospective study, 1470 medical files of patients with sarcoma who were referred during 1991-2002 to Imam Khomeini Hospital were studied. Sarcoma comprised 11% of all cases referring to our hospital. The mean age of patients with sarcoma was 30 years and male to female ratio was 3/2. Bone to soft tissue sarcoma ratio was 3.1 in children and 1.3 in adults. Osteosarcoma, Ewing and rhabdomyosarcoma presented 83% of children tumors, however, in adults osteosarcoma, synovial sarcoma and malignant fibrous histocytoma [MFH] were the most common subtypes. The main prognostic factors for survival were tumor size, margin of surgery, neurovascular involvement in pathological report, initial metastasis and complete response to initial therapy. Adjuvant radiotherapy, small tumor size, curative surgery with chemotherapy and free surgical margins were significantly associated with reduced recurrence. Complete response to primary therapy is the main independent variable of overall survival of patients. Earlier diagnosis and experienced team including surgical, medical and radiotherapy oncologist is needed for better response and longer survival rate

Determination of stool CEA level as a new screening test for large bowel cancer: preliminary study

The level of carcinoembryonic antigen [CEA] in stool and serum was determined in 31 patients with pathologically proven adenocarcinomas of the colon and rectum, and 25 control subjects. The level of stool CEA in patients with large bowel cancer was significantly greater [P < 0.0001] than that of the control group. Confirmation and clarification of this finding would form the basis of a simple, specific and sensitive screening test for colorectal cancer