RESUMO
Alkaptonuria, is a rare metabolic autosomal recessive disorder, which affects 1:1,000,000 people. It is also called endogenous ochronosis. Though it is mainly seen in children, in adults it usually presents after the age of 30.1 It arises from decreased activity of liver homogentisate 1,2-dioxygenase which leads to accumulation of homogentisic acid (HGA) and production of a melanin-like polymer which is deposited mainly in cartilaginous tissue, mucous, skin, bone surface, internal cardiac structures, as well as excreted in urine.2 The main presentation of alkaptonuria is valvular calcifications and osteoarthritis of spine, along with dark pigmentation of skin, cartilage, sclera and other connective tissues. It is diagnosed by a combination of clinical history, histopathological examination, and estimating the levels of homogentisic acid in urine.3
RESUMO
A 26 year old male presented to the emergency department with alleged history of RTA and sustained run over injury to right lower limb. On examination his vitals were HR-132/min. BP-70/42 mmHg SpO2 – 97% with room air. He was papery pale, drowsy and arousable to calls. A provisional diagnosis of severe hypovolemic shock was made. 16G Venflon was secured and resuscitation initiated with crystalloids and colloids. Blood samples sent for routine investigations (CBC, RFT) and blood grouping, typing and coagulation parameters. Meanwhile during resuscitation patient had cardiac arrest with asystole for which CPR initiated and ROSC achieved in 5 minutes. His haemoglobin levels were 5 g% with ABG showing mild metabolic and lactic acidosis. He was then stabilised with 3 units of PRBC in ER and shifted to CT scans. OF CASE
Assuntos
Aciclovir/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Anticonvulsivantes/uso terapêutico , Antivirais/uso terapêutico , Encéfalo/patologia , Criança , Coma/diagnóstico , Encefalomielite Aguda Disseminada/diagnóstico , Encefalomielite Aguda Disseminada/tratamento farmacológico , Evolução Fatal , Humanos , Imageamento por Ressonância Magnética , Masculino , Metilprednisolona/uso terapêutico , Fenitoína/uso terapêuticoRESUMO
Artemisia abrotanum Linn, belonging to family Asteraceae commonly known as [Southernwood] in Tamil. Hence, this species has not been scientifically evaluated; the present study was aimed to bring this plant under a suitable pharmacognostical scheme. This paper deals with the pharmacognostical studies carried out on the aerial parts of Artemisia abrotanum for identification and differentiation of the plant from other species of Artemisia