RESUMO
THE ANTITHYROID agents are of great therapeutic interest as they offer a method for correcting a hyperfunctioning gland without resort to surgery. They lower the metabolic rate by interfering with the synthesis, release or peripheral action of the thyroid hormone. The highly active antithyroid substances contain thiourea moieties, NHCSNH, capable of being easily oxidized. The suggestion has been made that the interference with thyroxine synthesis is by a direct reaction between I[2] and SH [formed by enolization] to form a disulphide [1-4]. The present communication deals with the synthesis and pharmacological studies of some N-aryl-N[']-benzoylthiocarbamides. The interest in the synthesis and pharmacological studies of these compounds as antithyroid drugs is due to the fact that acylisothiocyanates possess enhanced reactivity on account 0f the electron withdrawing acyl groups attached to the thioureidolinkage and the acylisothiocyanates on reaction with amino compounds usually give acylderivatives of thiocarbamides. The synthesis has been affected by the condensation of benzoylisothiocyanate [I] with different amines [II]