effect of chemotherapy on the serological response of patients with schistosoma haematobium infection using the enzyme linked immunosorbent assay [Elisa]

The enzyme linked immunosorbent assay [ELISA] was performed on blood samples obtained from 23 children found infected with Schistosoma haematobium before and three months after treatment with hycanthone. All of the children were negative by urine examination three months after treatment. Egg and worm antigens of S. mansoni were used in the assay. There was statistically significant decline in the level of antibodies against egg antigens but there was no difference in the level of antibodies against worm antigens. The comparability of the results with similar studies and their relevance to the interpretation of serological data obtained from epidemiological studies are discussed