Pharmacological study of Rasaraja Ras an Ayurvedic metal Preparation

Pharmacological effect of the drug Rasaraja Ras [RRR] was studied using albino mice. RRR reduced both spontaneous motor activity and, amphetamine induced hyperactivity. Conclusion from open field test, hole cross test, hole board test and climbing out test suggest a CNS depressant activity. But RRR did not potentiate pentobarbital sleeping time and it did not show any neurotoxicity or marked ataxia at this dose level. RRR exhibited analgesic activity and it lowered both the normal rectal temperature and pectin induced hyperthermia. On 24-hour metabolic studies RRR revealed reduction in food and water intake and also in defaecation. In 30-day growth study a dose dependent reduction in body weight gain was revealed