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1.
Journal of the Korean Surgical Society ; : 218-224, 1993.
Artigo em Coreano | WPRIM | ID: wpr-227673

RESUMO

No abstract available.


Assuntos
Tuberculose
2.
Journal of Korean Medical Science ; : 153-159, 1993.
Artigo em Inglês | WPRIM | ID: wpr-161571

RESUMO

c-erbB-2 oncogene encodes a growth factor receptor whose amino acid sequence has extensive homology with human epidermal growth factor receptor. It is frequently overexpressed in human breast, ovary, lung, and stomach cancers, where its overexpression is related significantly to the prognosis. Tl investigate the possible role of c-erbB-2 oncogene in the oncogenesis of stomach cancer, we examined the genetic alterations of c-erbB-2 oncogene in 4 stomach cancer cell lines, SNU-1, SNU-5, SNU-16 and KATO III. There were no differences in c-erbB-2 mRNA level as well as c-erbB-2 gene copy number among them. But gp185-erbB-2, c-erbB-2 gene product, was increased from 2- to 4-fold in SNU-1 and SNU-5 cells, compared with that in SNU-16 or KATO III cells. Our results suggest that post-transcriptional regulation of gp185erbB-2 expression may underlie gp185erbB-2 overexpression in cancer cells.


Assuntos
Humanos , Sequência de Aminoácidos , Dados de Sequência Molecular , Proteínas Tirosina Quinases/biossíntese , Proteínas Proto-Oncogênicas/biossíntese , RNA Mensageiro/análise , Receptores ErbB/biossíntese , Receptor ErbB-2 , Receptores de Superfície Celular/biossíntese , Neoplasias Gástricas/genética , Células Tumorais Cultivadas
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