Difference of Neuronal Recovery by Incubation Condition after Transient Hypoxia

No abstract available.

A Case of Metastatic Malignant Paraganglioma Causing Spinal Root Compression

Paragangliomas are neoplasms that arise from autonomic nervous system-associated paraganglia ; most often, they are benign, but have infrequently been reported to metastasize. Involvement of the spine is rare and is usually intradural at the level of the cauda equina. The authors report one case of metastatic malignant paraganglioma to the spine, which resulted in radiculopathy caused by extradural spinal root compression ; a review of the literature is also provided. Management of the reported patient involved spinal root decompression and spinal stabilization ; long-term symptom-free ambulatory status was maintained. After surgical removal of these tumors, radiation therapy may be an important adjunctive procedure.

MRI Diagnosis of a Ganglion Cyst of the Peroneal Nerve

A nerve ganglion cyst is characterized by the accumulation of a mucoid substance in or around the nerve, which leads to the formation of a pseudocyst. This 53-year-old man presented with left foot drop of three-year duration, using magnetic resonance imaging, 3-cm ganglion cyst of the peroneal nerve was preoperatively diagnosized. Surgical exploration disclosed a lobulated cystic mass filled with gelatinous material, and the lesion was completely resected. No connection with the knee joint was found, and postoperative recovery of motor function was good. The authors describe a case of intraneural ganglion cyst of the peroneal nerve which illustrates the value of MR in diagnostic imaging.

MRI Diagnosis of a Ganglion Cyst of the Peroneal Nerve

A nerve ganglion cyst is characterized by the accumulation of a mucoid substance in or around the nerve, which leads to the formation of a pseudocyst. This 53-year-old man presented with left foot drop of three-year duration, using magnetic resonance imaging, 3-cm ganglion cyst of the peroneal nerve was preoperatively diagnosized. Surgical exploration disclosed a lobulated cystic mass filled with gelatinous material, and the lesion was completely resected. No connection with the knee joint was found, and postoperative recovery of motor function was good. The authors describe a case of intraneural ganglion cyst of the peroneal nerve which illustrates the value of MR in diagnostic imaging.

Neuroprotective Effects of BAPTA-AM: A Dose-response Study and Estimation of Therapeutic Window

In central neurons, an excessive or sustained rise in the concentration of free cytoplasmic Ca2+ ions([Ca2+]i) after hypoxia may promote rapid neurodegeneration both in vitro and in vivo. Treating cells with Ca2+ chelating agents may prevent or delay a loss of cellular Ca2+ homeostasis after hypoxic injury and thus constitute an effective strategy for minimizing neuronal damage. Cell-permeant Ca2+ chelators such as 1,2-bis-(2-aminophenoxy) ethrane -N,N,N',N' -tetraacetic acid acetoxymethyl ester(BAPTA-AM) have shown evidence of neuroprotective effect against hypoxic neuronal injury. This study was designed to examine dose response and to estimate therapeutic window of BAPTA-AM for the recovery from hypoxia in vitro. Electrophysiological studies were made in CA1 neurons in rat hippocampal slices which were superfused with artificial cerebrospinal fluid(ASCF) in tissue chamber. Hypoxia was induced by replacement of 95% N2+5% CO2 from 95% O2+5% CO2 for 20min. Recovery from hypoxic injury was evaluated by using a percentage recovery of population spike. BAPTA-AM in concentration of 1, 10 and 50micrometer were administered to the artificial cerebrospinal fluid(ASCF) for 2 hours prior to hypoxia, simultaneous with hypoxia and after hypoxia. The experimental specimens were divided to seven groups and each group was compared to control ASCF group. Recovery of population spike after hypoxia was about 70% in control ASCF group, which was mild type hypoxic injury. BAPTA-AM in 10 micrometer concentration, when given just prior to hypoxia, enhanced recovery of poppulation spikes at 15 and 30min following reoxygenation(p<0.05), in comparison with control ASCF. BAPTA-AM had no neuroprotective acitvity when given after the onset of hypoxia. Also, BAPTA-AM in 1 and 50 micrometer concentration did not accentuate recovery of population spike after hypoxia. Dose response curve was inverted U-shape and the response was maximun in 10 micrometer concentration of BAPTA-AM.