A Case of Vestibular Schwannoma Treated with Revision Middle Cranial Fossa Approach to Preserve Facial Nerve Function and Hearing Ability / 대한이비인후과학회지

The aim of surgery for vestibular schwannoma is to accomplish complete tumor removal while preserving facial function and hearing ability. The middle cranial fossa approach represents one such surgical approach for resection of vestibular schwannoma with hearing preservation. As more experience has been gained with this approach, hearing preservation rates have increased. However, even if gross tumor removal is done completely, residual tumor can show regrowth microscopically. Such residual vestibular schwannoma may be treated by different options. We present a case of residual vestibular schwannoma treated with revision middle cranial fossa approach to preserve facial function and hearing ability.

Expression of Nonsteroidal Anti-Inflammatory Drug-Activated Gene(NAG-1) as a Prognostic Marker in Oral Tongue Squamous Cell Carcinoma / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Our previous study showed that nonsteroidal anti-inflammatory drug-activated gene (NAG-1) induced apoptosis in tongue cancer cells. However, the NAG-1 expression in tongue cancer and normal tissues was not studied. The aim of this study was to investigate the expression of NAG-1 in oral tongue cancer and normal tissues and to identify the relationship between NAG-1 expression and the prognosis of tongue cancer patients to determine whether NAG-1 can be used as a valuable prognostic marker in tongue cancer. SUBJECTS AND METHOD: The medical records and pathologic reports of 42 tongue cancer patients who received surgery as primary treatment were surveyed. Tongue cancer and normal tissues, which were obtained during the operation, were stained with anti-NAG-1 antibody using the immunohistochemical method and the H-score was calculated. RESULTS: As a result, the higher expression of NAG-1 was observed in the cancer tissues than in the normal tissues. NAG-1 expression was noted to be higher in cases of tongue cancers with more invasion, positive lymph node metastasis, and poor prognosis. A 5-year survival rate was significantly decreased in cases showing higher NAG-1 expression in the cancer tissues than in the normal tissues. CONCLUSION: The higher NAG-1 expression in the cancer tissue suggests malignant changes in cancer tissue and poor prognosis. Therefore, NAG-1 may be a useful prognostic marker in tongue squamous cell carcinoma.

A Case of Subepidermal Calcified Nodule in Auricle / 대한이비인후과학회지

Subepidermal calcified nodule, also called as cutaneous calculi, is a rare form of calcinosis cutis, which is not associated with biochemical abnormalities, or other dermatologic disorder or systemic illness. It occurs on the face and ear of children, and is asymptomatic. It usually presents as a solitary verrucous nodule and histologically shows as basophilic granules and masses in the dermis. We experienced one case of subepidermal calcified nodule in a 9-year-old boy with auricular mass. He did not have any other dermatologic disorder or systemic illnesses. Physical examination showed a 1.5 x 3 cm sized, non-tender, hard, fixed mass on left helix. It was surgically excised. It was finally reported as calcinosis cutis. We report it with a review of the current literature.

Case Report: Parotid Sialolithiasis / 대한이비인후과학회지

Salivary duct lithiasis is a condition characterized by the obstruction of a salivary gland or its excretory duct due to the formation of calcareous concretions or sialoliths resulting in salivary ectasia and even provoking the subsequent dilation of the salivary gland. It most commonly involves submandibular gland (80 to 90%) and less frequently parotid (10 to 20%). The authors report 2 cases of parotid sialolithiasis. The first case involved a 46-year-old male patient complaining of the left parotid area pain and swelling, and presenting with a salivary calculus in the left parotid duct. When the patient was diagnosed, he refused surgical removal. The second case involved a 41-year-old male patient complaining of the right parotid area pain and swelling, and presenting with a salivary calculus in the right parotid duct. The sialolith was surgically removed under general anesthesia. In this paper, we also reviewed a series of concepts related to the etiology, diagnosis and treatment of sialolithiasis.